794567-08-1

Upstream product

• 63366-76-7 (toluene-4-sulfonylamino)acetic acid benzyl ester 
• 78-94-4 methyl vinyl ketone 
• 770743-82-3 (2R,3R)-(-)-3-methyl-2-phenyl-1-(toluene-4-sulfonyl)pyrrolidin-3-ol 
• 944413-16-5 4-methyl-N-(3-oxobutyl)-N-(2-oxoethyl)benzenesulfonamide 
• 944413-14-3 N-allyl-4-methyl-N-(3-oxobutyl)benzenesulfonamide 
• 944413-15-4 C₁₄H₂₁NO₅S 
• 50487-71-3 4-methyl-N-(2-propenyl)benzenesulfonamide 
• 770743-81-2 (R)-(-)-2-phenyl-1-(toluene-4-sulfonyl)pyrrolidin-3-one 
• 770743-80-1 (R)-(+)-N-(p-toluenesulfonyl)-2-phenyl-3,3-(propanedisulfanyl)pyrrolidine 

Downstream Products

• 770743-83-4 (2S,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid methyl ester 
• 794567-06-9 (1S,5R)-5-methyl-2-(p-tolylsulfonyl)-6-oxa-2-aza-bicyclo[3.2.0]heptan-7-one 
• 681236-64-6 (2S,3R)-3-hydroxy-3-methylpyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

Organocatalytic synthesis of (2S,3R)-3-hydroxy-3-methyl-proline (OHMePro), a component of polyoxypeptins, and relatives using OHMePro itself as a catalyst

An efficient synthesis of (2S,3R)-3-hydroxy-3-methylproline (OHMePro), a component of polyoxypeptins, and relatives was achieved, in which an intramolecular asymmetric aldol reaction of the ketoaldehyde using OHMePro itself as an organocatalyst constitute

Asymmetric synthesis of α-amino 1,3-dithioketals from sulfinimines (N-sulfinyl imines). Synthesis of (2S,3R)-(-)-3-hydroxy-3-methylproline

(Chemical Equation Presented) N-Sulfinyl α-amino 1,3-dithioketals are prepared in high de and good yield by treating sulfinimines with lithio-1,3-dithianes. Selective removal of the N-sulfinyl or the thioketal groups affords stable α-amino 1,3-dithioketal

A short-step synthesis of (2S,3R)-3-hydroxy-3-methylproline, a component of polyoxypeptins, using a tandem Michael-aldol reaction and optical resolution

A short-step synthesis of (2S,3R)-3-hydroxy-3-methylproline, a component of polyoxypeptins, using a tandem Michael-aldol reaction followed by its optical resolution using (-)-cinchonidine has been achieved.