77113-85-0

Usage

Uses

Used in Agriculture and Animal Husbandry:
Flumethrin is used as an insecticide for controlling various ectoparasites such as ticks, mites, and lice on livestock. Its application helps in protecting the animals from the harmful effects of these parasites, which can cause discomfort, reduced productivity, and even transmit diseases.
The reason for its use in this industry is its effectiveness in targeting the nervous systems of insects, leading to their paralysis and death, while posing low toxicity risks to mammals.
Used in Veterinary Medicine:
In the veterinary medicine industry, flumethrin is utilized as a component in various formulations like ear tags, sprays, or pour-on solutions. These formulations are designed to provide a controlled release of the insecticide, ensuring a long-lasting effect against pests and reducing the need for frequent reapplication.
The application reason in this industry is the need for a reliable and long-lasting method to protect animals from ectoparasites, which can have detrimental effects on their health and well-being.

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Relevant academic research and scientific papers

Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum

The Ala16Val+Ser108Thr (A16V+S108T) mutant of the Plasmodium falciparum dihydrofolate reductase (DHFR) is a key mutant responsible for cycloguanil-resistant malaria due to steric interaction between Val-16 and one of the C-2 methyl groups of cycloguanil. 4,6-Diamino-1,2-dihydrotriazines have been prepared, in which both methyl groups of cycloguanil are replaced by H or by H and an alkyl or phenyl group, and their inhibition constants against wild-type and mutant DHFR determined. The S108T mutation is considered to decrease cycloguanil binding further through the effect on the orientation of the p-chlorophenyl group. By moving the p-chloro-substituent to the m-position in the chlorophenyl group, the activity against the A16V+S108T mutant enzyme is improved, and this effect is reinforced by the p-chloro substituent in the 3,4-dichlorophenyl group. A lead compound has been found with inhibitory activity similar to that of cycloguanil against the wild-type DHFR and about 120-fold more effective than cycloguanil against the A16V+S108T mutant enzyme. The activity of this compound against P. falciparum clone (T9/94 RC17) which harbors the A16V+S108T DHFR is about 85-fold greater than cycloguanil.