772-18-9

Usage

Uses

Used in Pharmaceutical Industry:
N-Ethyl 4-fluorobenzamide is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its benzamide structure allows it to serve as a precursor in the development of new drugs or treatments, potentially contributing to advancements in medicinal chemistry.
Used in Research Applications:
In the realm of scientific research, N-Ethyl 4-fluorobenzamide is employed as a building block for the synthesis of a variety of organic compounds. Its unique structure and properties make it a valuable tool for exploring new chemical reactions and developing novel organic molecules with potential applications in various fields.

Upstream product

• 328393-70-0 1-(4-fluorophenyl)propan-1-one oxime 
• 403-43-0 4-fluorobenzoyl chloride 
• 75-04-7 ethylamine 
• 456-22-4 4-Fluorobenzoic acid 
• 557-66-4 ethanamine hydrochloride 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 

Downstream Products

• 1246083-88-4 N-ethyl-4-(4-((2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide 
• 1246084-20-7 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethylbenzamide 
• 1246083-27-1 N-ethyl-4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide 
• 1018269-27-6 N-ethyl-4-(piperazin-1-yl)benzamide 
• 74554-78-2 N-acetyl-4-fluorobenzamide 
• 459-56-3 4-fluorobenzylic alcohol 
• 162401-03-8 N-(4-fluorobenzyl)ethanamine 

Relevant academic research and scientific papers

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Visible-Light-Driven Oxidation of N -Alkylamides to Imides Using Oxone/H 2 O and Catalytic KBr

Imides are prepared conveniently by visible-light-driven oxidations of various N -alkylamides under mild conditions. The majority of the reactions proceed efficiently by using Oxone as the oxidant in the presence of a catalytic amount of KBr in H 2 O/CH 2 Cl 2 under irradiation by an 8 W white LED at room temperature. Experimental studies suggest that an imine, obtained from the substrate amide via a radical process, is the key intermediate.

Tandem oxidative amidation of benzyl alcohols with amine hydrochloride salts catalysed by iron nitrate

A tandem process for the oxidative amidation of benzyl alcohols with amine hydrochloride salts has been developed using inexpensive Fe(NO3) 3 as the catalyst, air and aqueous t-butyl hydroperoxide as oxidants. A wide range of benzamides have been synthesized under mild conditions. This greener amide formation method provides an economical and practical assess to benzamides from readily available and inexpensive starting materials.

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors

Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose.

Poly (ADP-Ribose) Polymerase (PARP) INHIBITORS

Compounds of the following formula are provided for use with PARP: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds, methods and intermediates useful fo

Poly (ADP-Ribose) Polymerase (PARP) Inhibitors

Disclosed are compounds of the following formula: in which R1, R2, R3, R4, R5, R6, R7, X, and t are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.

POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS

Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds,

Rhodium-catalyzed Beckmann rearrangement

equation presented Beckmann rearrangement of oxime is catalyzed by [RhCl(cod)]2, trifluoromethanesulfonic acid, and tris(p-tolyl)phosphine in refluxing dichloroethane, giving the corresponding amide in good yield. Product/acid ratios of 10:20 can be attained in the reaction of benzophenone oximes.