77302-25-1Relevant academic research and scientific papers
Synthesis of substituted 4-arylpiperidin-2-ones by a 6-exo-trig radical cyclization
Vila, Xavier,Zard, Samir Z.
, p. 45 - 50 (2007/10/03)
A series of 5-substituted-4-arylpiperidin-2-ones have been synthesized in a 4 step sequence involving a radical 6-exo-trig cyclization as the key step.
Pallidium catalysed reactions of allenes, carbon monoxide and nucleophiles
Grigg, Ronald,Monteith, Michael,Sridharan, Visuvanathar,Terrier, Catherine
, p. 3885 - 3894 (2007/10/03)
Hydridopalladium(II) species generated in situ by oxidative addition of Pd(0) to acetic acid or acidic hydroxyl substrates (phenols, oximes) catalyse the termolecular assembly of allenes, CO and amines (primary, secondary) or oxygen nucleophiles to give methacrylamides or methacrylate esters and derivatives thereof in good to excellent yield.
Structure-activity relationship in cinnamamides. 3. Synthesis and anticonvulsant activity evaluation of some derivatives of (E)- and (Z)-m-(trifluoromethyl)cinnamamide
Balsamo,Crotti,Lapucci,Macchia,Macchia,Cuttica,Passerini
, p. 525 - 532 (2007/10/02)
The (E)- and (Z)-m-(trifluoromethyl)-α,β-dimethylcinnamamides and some of their N-alkyl derivatives were prepared and pharmacologically tested as anticonvulsant agents in order to verify if a ring substituent, like the m-CF3 group, different from a halogen but possessing the same electronic effect could lead to equally active compounds. Some (E)-m-(trifluoromethyl)-α-methyl- and -non-methyl-substituted-cinnamamides were also prepared and tested. In the α,β-dimethyl series, the results show that the m-CF3 group leads to products more active than the ones unsubstituted on the phenyl ring but still less active than the p-halogen-substituted compounds previously studied. In the α-methyl and non-methyl-substituted series, the trend shows the m-CF3 group being able to produce less toxic and, in some cases, more active products than the previously studied amides.
