773071-76-4

Basic information

• Product Name: methyl 2-amino-5-(2-methoxyethoxy)benzoate
• Synonyms: methyl 2-amino-5-(2-methoxyethoxy)benzoate
• CAS NO: 773071-76-4
• Molecular Weight: 225.244
• Mol File: 773071-76-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-amino-5-(2-methoxyethoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-amino-5-(2-methoxyethoxy)benzoate(773071-76-4)
• EPA Substance Registry System: methyl 2-amino-5-(2-methoxyethoxy)benzoate(773071-76-4)

Safety Data

• Hazardous Substances Data: 773071-76-4(Hazardous Substances Data)

Upstream product

• 610-37-7 5-hydroxy-2-nitrobenzoic acid 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 627-42-9 2-chloroethyl methyl ether 
• 1882-72-0 methyl 2-amino-5-hydroxybenzoate 

Relevant articles and documents

Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors

Fibroblast growth factor receptors (FGFRs) are important oncology targets due to the dysregulation of this signaling pathway in a wide variety of human cancers. We identified a series of pyrazolylaminoquinazoline derivatives as potent FGFR inhibitors with low nanomolar potency. The representative compound 29 strongly inhibited FGFR1-3 kinase activity and suppressed FGFR signaling transduction in FGFR-addicted cancer cells; FGFRs-driven cell proliferation was also strongly inhibited regardless of mechanistic complexity implicated in FGFR activation, which further confirmed that 29 was a potent pan-FGFR inhibitor. The flexibility of our structure offered the potential to preserve good affinity for mutant FGFR, which is important for developing TKIs with long-term efficacy.