77407-04-6

Upstream product

• 18424-76-5 dimethyl malonate sodium salt 
• 113526-04-8 2-(nitromethyl)-cyclohex-1-ene-3-one 
• 77406-95-2 6-Iodo-3-methoxymethoxy-2-methylene-hexanal 
• 77406-94-1 2-Diethoxymethyl-6-iodo-hex-1-en-3-ol 
• 77406-98-5 2-(1-Ethoxy-ethoxy)-7-iodo-4-methoxymethoxy-3-methylene-heptanenitrile 
• 107454-83-1 1-(nitromethyl)-1,2-epoxycyclohexane 
• 105956-40-9 2-(hydroxymethyl)cyclohex-2-en-1-one 
• 108-59-8 malonic acid dimethyl ester 
• 76047-55-7 2--2-cyclohexenone 
• 930-68-7 cyclohexenone 
• 108-94-1 cyclohexanone 
• 77406-92-9 2-methylene-3-(methoxymethyloxy) cyclohexanone 
• 125066-15-1 2-(phenylsulfonylmethyl)cyclohexenone 
• 77406-99-6 1-(1-Ethoxy-ethoxy)-3-methoxymethoxy-2-methylene-cyclohexanecarbonitrile 

Relevant academic research and scientific papers

Et3B-mediated and palladium-catalyzed direct allylation of β-dicarbonyl compounds with Morita-Baylis-Hillman alcohols

A practical and efficient palladium-catalyzed direct allylation of β-dicarbonyl compounds with both cyclic and acyclic Morita-Baylis-Hillman (MBH) alcohols, using Et3B as a Lewis acid promoter, is described herein. A wide range of the corresponding functionalized allylated derivatives have been obtained in good yields and with high selectivity.

Regioselective replacement of nitro or sulfonyl group in cyclic α-(nitroalkyl)- or α-(phenylsulfonylalkyl)enones by nucleophiles

Cyclic α-(nitroalkyl)enones and α-(phenylsulfonylalkyl)enones undergo regioselective substitution of the nitro group by relatively soft sulfur, nitrogen and carbon nucleophiles.

NEW SUBSTITUTION REACTION OF ALLYLIC NITRO COMPOUNDS. REGIOSELECTIVE REPLACEMENT OF NITRO GROUP IN CYCLIC α-(NITROALKYL)ENONES BY NUCLEOPHILES

Regioselective replacement of nitro group in cyclic α-(nitroalkyl)-enones by various nucleophiles such as stabilized carbanions, amine, NaN3, PhSO2Na and PhSNa provides the overall SN2 type products.

REGIOSPECIFIC CARBON-CARBON BOND FORMATION AT α AND β POSITIONS IN CYCLIC KETONES VIA DOUBLE MICHAEL ADDITION TO α-METHYLENE-β-ALKOXY CYCLIC KETONE

Very reactive 2-methylene-3-alkoxycyclohexanone was synthesized.The 1,4-conjugate addition of various nucleophiles to this enone gave only β'-alkylated 2-cyclohexenone with simultaneous elimination of the β-alkoxy group.The second 1,4-conjugate addition of other nucleophile to the resulting cyclohexenone leads to the α and β disubstituted ketones.