774210-59-2Relevant academic research and scientific papers
Development of carboxylic acid replacements in indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase
Stansfield, Ian,Pompei, Marco,Conte, Immacolata,Ercolani, Caterina,Migliaccio, Giovanni,Jairaj, Mark,Giuliano, Claudio,Rowley, Michael,Narjes, Frank
, p. 5143 - 5149 (2008/02/12)
Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here 2 series of indole-N-acetamides, bearing
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase
Harper, Steven,Avolio, Salvatore,Pacini, Barbara,Di Filippo, Marcello,Altamura, Sergio,Tomei, Licia,Paonessa, Giacomo,Di Marco, Stefania,Carfi, Andrea,Giuliano, Claudio,Padron, Julio,Bonelli, Fabio,Migliaccio, Giovanni,De Francesco, Raffaele,Laufer, Ralph,Rowley, Michael,Narjes, Frank
, p. 4547 - 4557 (2007/10/03)
Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. Compounds that block replication of subgenomic HCV RNA in liver cells are of interest because of their demonstrated antivir
