774213-84-2

Usage

Indole ring

The chemical structure of the compound contains an indole ring, which is a tricyclic aromatic system consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing ring.

Butyric acid side chain

The compound has a butyric acid side chain, which is a four-carbon chain (CH3-CH2-CH2-COOH) attached to the indole ring.

Cyclohexyl group

The compound features a cyclohexyl group (C6H11), a cyclic alkyl group consisting of six carbon atoms, attached to the indole ring.

Methoxycarbonyl group

The compound contains a methoxycarbonyl group (OCH3-COO-), which is a carbonyl group (C=O) functional group esterified with a methoxy group (OCH3).

Plant growth regulator

1H-Indole-1-acetic acid, 3-cyclohexyl-6-(methoxycarbonyl)-2-phenyl-, 1,1-dimethylethyl ester is a synthetic plant hormone and a potential plant growth regulator, making it useful for managing plant growth and development.

Horticultural applications

In horticulture, IBA is commonly used to stimulate root development in cuttings, promote flowering, and enhance fruit set, improving plant propagation and growth.

Tissue culture

The compound is also employed in tissue culture techniques to induce root formation, prevent leaf yellowing, and avoid abscission, making it an essential tool in plant tissue culture practices.

Upstream product

• 494799-14-3 3-cyclohexyl-2-phenylindole-6-carboxylic acid methyl ester 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 774213-79-5 methyl 2-bromo-1-(2-tert-butoxy-2-oxoethyl)-3-cyclohexyl-1H-indole-6-carboxylate 
• 98-80-6 phenylboronic acid 
• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 108-94-1 cyclohexanone 
• 494799-16-5 3-(cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid 
• 494799-17-6 3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid 
• 494799-18-7 methyl 3-cyclohexyl-1H-indole-6-carboxylate 

Downstream Products

• 735282-89-0 3-cyclohexyl-1-(2-morpholin-4-yl-2-oxoethyl)-2-phenyl-1H-indole-6-carboxylic acid 
• 774213-90-0 2-(6-cyano-3-cyclohexyl-2-phenyl-1H-indole-1-yl)-N,N-dimethylacetamide 
• 774213-89-7 3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxamide 

Relevant academic research and scientific papers

Antiviral indoles

Compounds of the formula (I): wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed.

Development of carboxylic acid replacements in indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase

Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here 2 series of indole-N-acetamides, bearing

Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase

Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here a novel class of allosteric inhibitor of NS5B that shows potent affinity for the NS5B enzyme and effective inhibition of subgenomic HCV RNA replication in HUH-7 cells. Inhibitors from this class have promising characteristics for further development as anti-HCV agents.

INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE

The present invention relates to indole and azaindole compounds of formula (I): wherein X1, X2, X3, X4, A1, Ar1, R1, R2 and n are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.