77447-99-5Relevant academic research and scientific papers
4-Substituted-2-oxoazetidine compounds
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, (2008/06/13)
The present invention relates to novel 4-substituted-2-oxoazetidine compounds and to processes for preparing the same. These compounds are useful intermediates for preparing antibiotics having the basic skeleton of Thienamycin.
4-Substituted-2-oxoazetidine compounds and processes for the preparation thereof
-
, (2008/06/13)
This invention relates to novel 4-substituted-2-oxoazetidine compounds and salts thereof, which are useful intermediates in the preparation of antibiotics having the fundamental skeleton of Thienamycin, which compounds are of the formula: STR1 in which R
Synthesis of β-lactam antibiotics by the sulfeno-cycloamination
Ihara,Haga,Yonekura,et al.
, p. 7345 - 7352 (2007/10/02)
A novel efficient beta -lactam synthesis was achieved by two successive processes (sulfeno-cycloamination), addition of phenysulfenyl chloride to alpha , beta -unsaturated amides followed by base treatment. Key synthetic intermediates of monobactams and nocardicin derivatives were obtained via this method. construction of the 1-carbapenam ring system by the sulfenocycloamination is also described.
Total Synthesis of (+/-)-Epithienamycins A and B and Derivatives
Kametani, Tetsuji,Huang, Shyh-Pyng,Nagahara, Takayasu,Ihara, Masataka
, p. 2282 - 2286 (2007/10/02)
(+/-)-(3R*,4R*)-4-(2,2-Dimethoxyethyl)-3-*)-1-hydroxyethyl>azetidin-2-one (7), which has been stereoselectively synthesised via the 4-methoxycarbonylisoxazoline (4), was converted into (+/-)-epithienamycins A (2) and B
Studies on the Syntheses of Heterocyclic Compounds. Part 877. An Alternative Synthesis of Protected (+/-)-Thienamycin and a Related Compound
Kametani, Tetsuji,Huang, Shyh-Pyng,Nagahara, Takayasu,Yokohama, Shuichi,Ihara, Masataka
, p. 964 - 968 (2007/10/02)
An alternative total synthesis of protected (+/-)-thienamycin (2) and an analogue is described. (+/-)-4β-(2,2-Dimethoxyethyl)-3α-*)-1-(-nitrobenzyloxycarbonyloxy)ethyl>azetidin-2-one (5), prepared from isoxazoline derivatives (4), was conve
TOTAL SYNTHESIS OF (+/-)EPITHIENAMYCINS A AND B
Kametani, Tetsuji,Huang, Shyh-Pyng,Nagahara, Takayasu,Ihara, Masataka
, p. 65 - 70 (2007/10/02)
(+/-)-3R*-(1'S*-Hydroxyethyl)-4R*-(2',2'-dimethoxyethyl)-2-azetidinone (6), which was obtained from the 4-methoxycarbonylisoxazoline (4) as a major product, was converted into (+/-)-epithienamycins A(2) and B(3) vi
Studies on the Syntheses of Heterocyclic Compounds. 800. A Formal Total Synthesis of (+/-)-Thienamycin and (+/-)-Decysteaminylthienamycin Derivative
Kametani, Tetsuji,Huang, Shyh-Pyng,Yokohama, Shuichi,Suzuki, Yukio,Ihara, Masataka
, p. 2060 - 2065 (2007/10/02)
The synthesis of a key intermediate for the preparation of (+/-)-thienamycin (1) and its derivatives has been developed.By 1,3-dipolar cycloaddition, the nitrile oxide derived from 3-nitropropanal dimethyl acetal (3) was added to methyl crotonate to give
AN ALTERNATIVE TOTAL SYNTHESIS OF (+/-)-THIENAMYCIN
Kametani, Tetsuji,Huang, Shyh-Pyng,Nagahara, Takayasu,Ihara, Masataka
, p. 1305 - 1308 (2007/10/02)
(+/-)-4β-(2',2'-Dimethoxyethyl)-3α-(1'R*)-p-nitrobenzylocarbonyloxyethyl)-2-azetidinone (4) was converted into the thienamycin derivative (2) protected with p-nitrobenzyl group, utilizing the carbene insertion reaction and subsequent introduction of the c
