76335-76-7

Upstream product

• 73659-95-7 (6RS,7SR)-7-acetyl-8-oxo-3-oxa-1-aza-bicyclo[4.2.0]octane-2-spirocyclohexane 
• 72789-82-3 (3S,4R)-4-(2,2-dimethoxyethyl)-3-[(1RS)-1-(p-nitrobenzyloxycarbonyloxy)ethyl]-2-oxoazetidine 
• 72789-82-3 (+/-)-4β-(2',2'-dimethoxyethyl)-3α-((1'R*)-p-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone 
• 64066-71-3 (3S,4R)-3-[(1RS)-1-(p-nitrobenzyloxycarbonyloxy)ethyl]-4-(2-oxoethyl)-2-oxoazetidine 
• 64066-71-3 Carbonic acid 4-nitro-benzyl ester (S)-1-[(3R,4S)-2-oxo-4-(2-oxo-ethyl)-azetidin-3-yl]-ethyl ester 
• 74819-50-4 C₂₁H₂₆N₂O₇ 
• 73155-38-1 (6RS,7RS,9RS)-7-(1-hydroxyethyl)-8-oxo-3-oxa-1-azabicyclo<4.2.0>octane-2-spirocyclohexane 
• 72690-84-7 (3RS,4RS)-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>azetidin-2-one 
• 74819-50-4 C₂₁H₂₆N₂O₇ 
• 73155-38-1 (6RS,7RS,9SR)-7-(1-hydroxyethyl)-8-oxo-3-oxa-1-azabicyclo<4.2.0>octane-2-spirocyclohexane 
• 106673-93-2 (6RS,9SR)-7-(1-hydroxyethyl)-8-oxo-7-(toluene-p-sulphenyl)-3-oxa-1-azabicyclo<4.2.0>octane-2-spirocyclohexane 
• 106673-89-6 7-acetyl-8-oxo-7-(toluene-p-sulphenyl)-3-oxa-1-azabicyclo<4.2.0>octane-2-spirocyclohexane 
• 106673-90-9 7-acetyl-7-methylthio-8-oxo-3-oxa-1-azabicyclo<4.2.0>octane-2-spirocyclohexane 
• 106673-92-1 7-acetyl-7-bromo-8-oxo-3-oxa-1-azabicyclo<4.2.0>octane-2-spirocyclohexane 

Downstream Products

• 76347-45-0 (+/-)-3β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-4β-(3-p-nitrobenzyloxycarbonyl-2-oxopropyl)azetidin-2-one 
• 76335-78-9 (5RS,6RS,8RS)-p-nitrobenzyl 3,7-dioxo-6-(1-p-nitrobenzyloxycarbonyloxyethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 76347-45-0 p-nitrobenzyl (3RS,4RS)-4-<3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-4-yl>-3-oxobutanoate 
• 133380-98-0 (5RS,6RS,8RS)-p-nitrobenzyl 3-diphenylthiophosphinoyl-6-(1-p-nitrobenzyloxycarbonyloxyethyl)-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 65991-26-6 (5RS,6RS,8RS)-p-nitrobenzyl 3-<2-(p-nitrobenzyloxycarbonylamino)ethylthio>-6-(1-p-nitrobenzyloxycarbonyloxyethyl)-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 76347-45-0 (+/-)-3α-<(1R^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-4β-(3-p-nitrobenzyloxycarbonyl-2-oxopropyl)azetidin-2-one 
• 78072-33-0 (+/-)-3α-<(1R^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-4β-<(phenylthio)carbonylmethyl>azetidin-2-one 
• 76335-78-9 (+/-)-p-nitrobenzyl 6α-<(1R^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-3,7-dioxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 65991-26-6 (+/-)-p-nitrobenzyl 3-<2-(p-nitrobenzyloxycarbonylamino)ethylthio>-6α-<(1R^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 78072-37-4 Hydroxy-{(3S,4R)-3-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-2-oxo-4-phenylsulfanylcarbonylmethyl-azetidin-1-yl}-acetic acid 4-nitro-benzyl ester 
• 78072-34-1 (+/-)-3α-<(1R^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-1--4β-<(phenylthio)carbonylmethyl>azetidin-2-one 
• 78072-31-8 Hydroxy-{(2R,3S)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanylcarbonylmethyl]-3-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-acetic acid 4-nitro-benzyl ester 
• 78072-32-9 (+/-)-4α-<<2-(p-nitrobenzyloxycarbonylamino)ethylthio>carbonylmethyl>-3β-<(1R^*)-1(p-nitrobenzyloxycarbonyloxy)ethyl>-1-azetidin-2-one 
• 78072-35-2 (+/-)-p-nitrobenzyl 6α-<(1R^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-7-oxo-3-phenylthio-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 

Relevant academic research and scientific papers

Olivanic Acid Analogues. Part 8. Halogenation and Sulphenylation Reactions leading Selectively to cis-Carbapenem Precursors; Stereospecific Synthesis of (+/-)-6-Epithienamycin

Introduction of halogen or sulphenyl substituents at C-7 of ketone 1, followed by stereospecific reduction steps, provides a selective route either to the (6RS,7RS,9RS) isomer 11 or to the (6RS,7RS,9SR) isomer 14 of 7-(1-hydroxyethyl)-8-oxo-3-oxa-1-azabic

Sulphenylation and Halogenation Reactions leading Selectively to cis-Carbapenem Precursors; Stereospecific Synthesis of (+/-)-6-Epithienamycin

Introduction of sulphenyl or halogen substituents at C-7 of ketone (1), followed by stereospecific reduction steps, provides a selective route either to the (6RS,7RS,9SR) or to the (6RS,7RS,9RS) isomers, (10) and (11), of 7-(1-hydroxyethyl)-8-oxo-1-aza-3-

Studies on the Syntheses of Heterocyclic Compounds. Part 877. An Alternative Synthesis of Protected (+/-)-Thienamycin and a Related Compound

An alternative total synthesis of protected (+/-)-thienamycin (2) and an analogue is described. (+/-)-4β-(2,2-Dimethoxyethyl)-3α-*)-1-(-nitrobenzyloxycarbonyloxy)ethyl>azetidin-2-one (5), prepared from isoxazoline derivatives (4), was conve

Total Synthesis of (+/-)-Epithienamycins A and B and Derivatives

(+/-)-(3R*,4R*)-4-(2,2-Dimethoxyethyl)-3-*)-1-hydroxyethyl>azetidin-2-one (7), which has been stereoselectively synthesised via the 4-methoxycarbonylisoxazoline (4), was converted into (+/-)-epithienamycins A (2) and B

TOTAL SYNTHESIS OF (+/-)EPITHIENAMYCINS A AND B

(+/-)-3R*-(1'S*-Hydroxyethyl)-4R*-(2',2'-dimethoxyethyl)-2-azetidinone (6), which was obtained from the 4-methoxycarbonylisoxazoline (4) as a major product, was converted into (+/-)-epithienamycins A(2) and B(3) vi

AN ALTERNATIVE TOTAL SYNTHESIS OF (+/-)-THIENAMYCIN

(+/-)-4β-(2',2'-Dimethoxyethyl)-3α-(1'R*)-p-nitrobenzylocarbonyloxyethyl)-2-azetidinone (4) was converted into the thienamycin derivative (2) protected with p-nitrobenzyl group, utilizing the carbene insertion reaction and subsequent introduction of the c