7747-18-4

Upstream product

• 326907-47-5 2,5-diphenyl-5,6-dihydro-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-one 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 3414-94-6 5-phenyl-1H-1,2,4-triazole-3-thiol 
• 65-85-0 benzoic acid 
• 5351-66-6 benzoyl thiosemicarbazide 
• 613-94-5 benzoic acid hydrazide 
• 93-58-3 benzoic acid methyl ester 
• 3414-94-6 5-phenyl-4H-1,2,4-triazol-3-thiol 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 96133-99-2 C₁₀H₁₃N₃OS 

Relevant academic research and scientific papers

Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction

Defective in cullin neddylation 1(DCN1) is a co-E3 ligase that is important for cullin neddylation. Dysregulation of DCN1 highly correlates with the development of various cancers. Herein, from the initial high-throughput screening, a novel hit compound 5a containing a phenyltriazole thiol core (IC50 value of 0.95 μM for DCN1-UBC12 interaction) was discovered. Further structure-based optimization leads to the development of SK-464 (IC50 value of 26 nM). We found that SK-464 not only directly bound to DCN1 in vitro, but also engaged cellular DCN1, suppressed the neddylation of cullin3, and hindered the migration and invasion of two DCN1-overexpressed squamous carcinoma cell lines (KYSE70 and H2170). These findings indicate that SK-464 may be a novel lead compound targeting DCN1-UBC12 interaction.

Synthesis and evaluation of some Triazole derivatives as corrosion inhibitors and biocides

Three compounds namely; 5-(phenyl)-4H-1,2,4-triazole-3-thiol, 3-(decylthio)-5-phenyl-1H-1,2,4-triazole and 3-(benzylthio)-5-phenyl-1H-1,2,4- triazole) were synthesized. The chemical structure of the prepared compounds was confirmed using FTIR and 1H-NMR analysis. The compounds were tested as corrosion inhibitors against the corrosion of carbon steel in 1 M HCl using weight loss, polarization and electrochemical impedance methods. The results revealed that these compounds have significant inhibiting effects on the corrosion of carbon steel. Polarization studies showed that the compounds act as mixed-type inhibitors which retard the anodic and the cathodic reactions with a predominant effect towards the cathodic reaction. The prepared compounds were evaluated as antimicrobial agents against sulfate-reducing bacteria using the serial dilution method, which showed good biocidal action.

Reaction of 2-aryl-5-R-5,6-dihydro-7H-[1,2,4]-triazolo[5,1-b][1,3]thiazin- 7-ones with aryl bromomethyl ketones and benzyl bromide

The products of the reaction of 2-aryl-5-R-5,6-dihydro-7H-[1,2,4] triazolo[5,1-b][1,3]thiazin-7-ones with aryl bromomethyl ketones are 2-aryl-7H-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-ones and aryl methyl ketones or 2,5-diaryl[1,3]thiazolo[3,2-b][1,2,4]tria

Derives de la dihydro-2,4 triazole-1,2,4 thione-3 et de l'amino-2 thiadiazole-1,3,4 a partir de nouvelles thiosemicarbazones d'esters

A new general synthesis of 4,5-disubstituted 2,4-dihydro-1,2,3-triazole-3-thiones is proposed.These heterocycles are obtained by the action of primary amines, aralhydrazines or aroylhydrazines on the thiosemicarbazones of esters.These last compounds are prepared by action of chlorhydrates of iminoesters on thiosemicarbazide in dimethylformamide.These thiosemicarbazones react also with strong acids, acid anhydrides and chlorides; by thermolysis and they give 2-amino-1,3,4-thiadiazole derivatives.Also, two derivatives of 1,2,4-triazolo-1,3,4-thiadiazole have been prepared.