77489-36-2Relevant academic research and scientific papers
Synthesis and characterization of some novel thiosemicarbazones of substituted benzaldehydes and N-(Hepta-O-Acetyl-β-D-Lactosyl) thiosemicarbazide
Thanh, Nguyen Dinh,Van, Hoang Thi Kim,Thu, Truong Thi
, p. 514 - 544 (2015)
A set of reaction conditions, including ionic liquids as catalysts, water as solvent and microwave-assisted heating method, had been investigated for the synthesis of hepta-O-acetyl-β-D-lactosyl thiosemicarbazones. Based on optimized conditions, namely, [
New synthetic approach to per-O-acetyl-isocyanates, isothiocyanates and thioureas in the disaccharide and cyclodextrin series
Menuel, Stephane,Porwanski, Stanislaw,Marsura, Alain
, p. 603 - 608 (2006)
An efficient method for the preparation of per-O-acetyl disaccharides and cyclodextrin isocyanates or isothiocyanates by the phosphine imide strategy is reported. Successful one-pot, high yield syntheses of cellobiose, lactose and sucrose isocyanates or/a
Synthesis and Antimicrobial Activities of 1,2,4-Thiadiazolidin-3-thione Hydrochlorides
Mangte, Anvita D.,Nayak, Riddhi A.
, p. 77 - 83 (2022/03/27)
Synthesis of N-glucosyl/lactosyl/maltosyl-1,2,4-thiadizolidin-3-thione hydrochlorides by the reaction of N-phenyl-S-chloroisothiocarbamoyl chloride and N-glucosyl/lactosyl/maltosyl thiocarbamides is reported. The simple isolation method with good yields under mild condition is applicable for the present protocol. All the newly synthesized thiadiazolidin-3-thiones exhibit moderate to good antimicrobial activities against a variety of pathogen
Synthesis and antimicrobial studies of novel n-glycosyl hydrazino carbothioamide
Nayak, Riddhi A.,Mangte, Anvita D.
, p. 127 - 131 (2021/01/06)
In view of applications of N-glycosylated compounds in medicinal chemistry and in many other ways, herein the synthesis of novel N-glycosyl hydrazino carbothioamides is reported. New N-glycosyl hydrazino carbothioamides were synthesized by the condensation of per-O-acetyl glycosyl isothiocyanate with different aromatic hydrazides. The newly synthesized compounds were characterized by using the IR, 1H NMR and mass spectral studies. Antimicrobial evaluation of the synthesized N-glycosyl hydrazino carbothioamide was also examined. Antimicrobial activities of the synthesized compound were evaluated against bacteria E. coli, P. aeruginosa, S. aureus, S. pyogenus and fungi C. albicans, A. niger and A. clavatus. All the N-glycosyl hydrazino carbothioamides exhibit promising antimicrobial activity.
Synthesis of some new carbohydrate-containing thiouriedonaphtho-quinones
Salameh, Bader A.,Al-Qawasmeh, Raed A.,Al-Jabari, Kumait,Voelter, Wolfgang
, p. 2929 - 2937 (2015/04/27)
Abstract New alkyl, aryl, and glycosylthiouriedo derivatives of 2,3-diamino-1,4-naphthoquinone were synthesized via the reaction of isothiocyanates with 2,3-diamino-1,4-naphthoquinone. The new compounds were fully characterized through their physicochemical properties.
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases
Moeker, Janina,Teruya, Kanae,Rossit, Sabine,Wilkinson, Brendan L.,Lopez, Marie,Bornaghi, Laurent F.,Innocenti, Alessio,Supuran, Claudiu T.,Poulsen, Sally-Ann
scheme or table, p. 2392 - 2404 (2012/05/05)
A library of 32 novel glycoconjugate thiourea-bridged benzene sulfonamides have been synthesized from the reaction of glycosyl isothiocyanates with a panel of simple benzene sulfonamides comprising either a free amine or hydrazide. All compounds were inve
Comparative study of microwave induced and conventional synthesis of acetylated sugar isothiocyanates and related thiocarbamides
Yadgire, Atul V.,Korpe, Gajanan V.,Deshmukh, Shirish P.
, p. 1614 - 1619 (2012/05/05)
The synthesis of several acetylated sugar isothiocyanates have been carried out under microwave irradiation in excellent yields of products by using related bromides and lead thiocyanate in sodium dried xylene. Several acetylated sugar thiocarbamides have been synthesized by the interaction of respective acetylated sugar isothiocyanates with appropriate aryl amines under microwave irradiation. Copyright E-Journal of Chemistry 2004-2011.
Synthesis of some novel substituted benzaldehyde (hepta-O-acetyl-β- maltosyl)thiosemicarbazones
Thanh, Nguyen Dinh,Van, Hoang Thi Kim
experimental part, p. 4263 - 4267 (2012/02/01)
(Hepta-O-acetyl-β-maltosyl)thiosemicarbazide was synthesized from peracetated β-maltosyl isothiocyanate by reaction with hydrazine hydrate. A series of substituted benzaldehyde (hepta-O-acetyl-β-maltosyl) thiosemicarbazones were synthesized by condensation reactions of (hepta-O-acetyl-β-maltosyl)thiosemicarbazide with corresponding substituted benzaldehydes using microwave-assisted method.
A novel, simple cyclocondensation reaction towards glycosyl triazines
Kikelj, Vincent,Julienne, Karine,Janvier, Pascal,Meslin, Jean-Claude,Deniaud, David
scheme or table, p. 3453 - 3460 (2009/05/26)
Sugars bearing an isothiocyanate moiety at C-1 react with diazadienium iodide to afford glycosyl triazines that represent, through an easy cyclocondensation reaction step, a flexible entry to different nucleoside analogues. We herein demonstrate that this [4+2] cycloaddition reaction occurs with total regiocontrol and good yields. Subsequent transformation of the thiocarbonyl into a carbonyl, and nucleophilic substitution of the methylsulfanyl group by ammonia, yields the 5-azacytidine analogues. All compounds were fully characterised by IR, HRMS, and 13C and 1H NMR (COSY, HMBC and HMQC). Georg Thieme Verlag.
Synthesis of α- and β-glycosyl isothiocyanates via oxazoline intermediates
Blanco, Jose L. Jimenez,Sylla, Balla,Mellet, Carmen Ortiz,Fernandez, Jose M. Garcia
, p. 4547 - 4550 (2008/02/05)
(Chemical Equation Presented) A practical synthesis of acylated glycosyl isothiocyanates from sugar oxazolines, by reaction with thiophosgene, is reported. In the absence of any additive, the reaction is governed by the reverse anomeric effect, leading to
