7750-16-5

Basic information

• Product Name: 2-chloro-N-[(S)-(1-ethoxycarbonyl-2-phenyl)ethyl]ethanamide
• CAS NO: 7750-16-5
• Molecular Weight: 269.728
• Mol File: 7750-16-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-[(S)-(1-ethoxycarbonyl-2-phenyl)ethyl]ethanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-[(S)-(1-ethoxycarbonyl-2-phenyl)ethyl]ethanamide(7750-16-5)
• EPA Substance Registry System: 2-chloro-N-[(S)-(1-ethoxycarbonyl-2-phenyl)ethyl]ethanamide(7750-16-5)

Safety Data

• Hazardous Substances Data: 7750-16-5(Hazardous Substances Data)

Upstream product

• 3182-93-2 (L)-phenylalanine ethyl ester hydrochloride 
• 79-04-9 chloroacetyl chloride 
• 3081-24-1 H-Phe-OEt 
• 1795-96-6 phenylalanine ethyl ester 
• 7765-11-9 N-chloroacetyl-DL-phenylalanine 

Downstream Products

• 952428-99-8 1,4,7-tris[(S)-{(1-ethoxycarbonyl-2-phenyl)ethyl}-carbamoylmethyl]-1,4,7,10-tetraazacyclododecane 
• 1367887-21-5 C₁₄₀H₁₇₂N₄O₂₀ 
• 76385-62-1 (S)-ethyl 2-(2-(diethoxyphosphoryl)acetamido)-3-phenylpropanoate 
• 19700-60-8 2-[2-(Diethoxy-thiophosphorylsulfanyl)-acetylamino]-3-phenyl-propionic acid ethyl ester 
• 23701-47-5 2-[2-(Diisopropoxy-thiophosphorylsulfanyl)-acetylamino]-3-phenyl-propionic acid ethyl ester 
• 76385-72-3 (S)-3-Phenyl-2-(2-phosphono-acetylamino)-propionic acid ethyl ester 

Relevant articles and documents

New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain

The heterotrimeric influenza virus polymerase performs replication and transcription of viral RNA in the nucleus of infected cells. Transcription by "cap-snatching" requires that host-cell pre-mRNAs are bound via their 5′ cap to the PB2 subunit. Thus, the PB2 cap-binding site is potentially a good target for new antiviral drugs that will directly inhibit viral replication. Docking studies using the structure of the PB2 cap-binding domain suggested that 7-alkylguanine derivatives substituted at position N-9 and N-2 could be good candidates. Four series of 7,9-di- and 2,7,9-trialkyl guanine derivatives were synthesized and evaluated by an AlphaScreen assay in competition with a biotinylated cap analogue. Three synthesized compounds display potent in vitro activity with IC50 values lower than 10 μM. High-resolution X-ray structures of three inhibitors in complex with the H5N1 PB2 cap-binding domain confirmed the binding mode and provide detailed information for further compound optimization.

Towards aqueous chiral heptadentate lanthanide complexes as selective shift and relaxation agents for MRS

Magnetic resonance spectroscopy (MRS) is of prime importance in diagnostics and offers a means of analyzing, in vivo, the chemical content of living tissue, as a non-invasive alternative to biopsy. Several heptadentate, lanthanide complexes have been synt

Inhibitors of Pyrimidine Biosynthesis. Part 1. Synthesis of Potential Transition-state Analogues of Aspartate Transcarbamylase

A systematic variation of the structure of a transition-state analogue of aspartate transcarbamylase has been carried out.A new, and general, synthesis of these analogues, starting from the appropriate amino-acid is described.