79089-63-7

Basic information

• Product Name: N-benzhydrylmorpholine
• Synonyms: N-benzhydrylmorpholine
• CAS NO: 79089-63-7
• Molecular Weight: 253.344
• Mol File: 79089-63-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N-benzhydrylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzhydrylmorpholine(79089-63-7)
• EPA Substance Registry System: N-benzhydrylmorpholine(79089-63-7)

Safety Data

• Hazardous Substances Data: 79089-63-7(Hazardous Substances Data)

Upstream product

• 1078-58-6 diphenylzinc 
• 110-91-8 morpholine 
• 908093-98-1 diazodiphenylmethane 
• 781-35-1 1,1-diphenylacetone 
• 108-86-1 bromobenzene 
• 103-79-7 1-phenyl-acetone 
• 101-81-5 Diphenylmethane 
• 6425-08-7 4,4'-(phenylmethylene)bismorpholine 
• 98-80-6 phenylboronic acid 
• 100-52-7 benzaldehyde 
• 4545-20-4 benzophenone tosylhydrazone 
• 776-74-9 Bromodiphenylmethane 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 101584-54-7 4-benzhydryloxy-morpholine 
• 102890-48-2 4-benzhydryl-morpholine-4-oxide 

Relevant articles and documents

Atom-efficient transition-metal-free arylation ofN,O-acetals using diarylzinc reagents through Zn/Zn cooperativity

Exploiting the cooperative action of Lewis acid Zn(C6F5)2with diarylzinc reagents, the efficient arylation ofN,O-acetals to access diarylmethylamines is reported. Reactions take place under mild reaction conditions without the need for transtion-metal catalysis. Mechanistic investigations have revealed that Zn(C6F5)2not only acts as a Lewis acid activator, but also enables the regeneration of nucleophilic ZnAr2species, allowing a limiting 50 mol% to be employed.

Benzyl C–O and C–N Bond Construction via C–C Bond Dissociation of Oxime Ester under Visible Light Irradiation

A photoredox benzyl activation was developed via formidable C(sp3)–C(sp3) bond dissociation of 1-aryl acetone oxime esters, which were easily prepared from benzyl ketones. Further coupling with O- and N- nucleophiles successfully forged important benzyl ether and amines derivatives in one pot. In this process, different substitutions on oxime esters were found compatible and various primary and secondary alcohols and amines, as well as amides showed good performance as nucleophiles. Mechanistic studies by control experiments, electrochemical measurements and in-situ NMR spectra proposed a N–O bond interruption/C–C bond fragmentation/oxidation sequence to provide the key cation intermediate for the next electrophilic SN process. The features of mild condition, short reaction time and broad substrate scope made this new strategy much promising in the transformation of benzyl compounds, which might be valuable in last-stage functionalizations.

Visible-light-mediated benzylic sp3 C-H bond functionalization to C-Br or C-N bond

A visible-light-promoted functionalization of unactivated benzylic sp3 C-H bonds was developed. Ethylbenzene derivatives were converted to the corresponding benzyl bromides or afforded benzylamine derivatives in a one-pot manner under visible light photoredox conditions.