77612-17-0

Basic information

• Product Name: CIS-2-BENZYLAMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE
• Synonyms: CIS-2-BENZYLAMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE;cis-2-benzylaminomethyl-1-cyclohexanolHCl;cis-2-Benzylaminomethyl-1-cyclohexanol hydrochloride,98%
• CAS NO: 77612-17-0
• Molecular Formula: C₁₄H₂₁NO
• Molecular Weight: 255.78
• Mol File: 77612-17-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 167-170 °C
• Boiling Point: 347.63 °C at 760 mmHg
• Flash Point: 107.597 °C
• Appearance: /
• Density: 1.041±0.06 g/cm3(Predicted)
• Vapor Pressure: 0mmHg at 25°C
• PKA: 15.12±0.40(Predicted)
• CAS DataBase Reference: CIS-2-BENZYLAMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-2-BENZYLAMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE(77612-17-0)
• EPA Substance Registry System: CIS-2-BENZYLAMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE(77612-17-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 77612-17-0(Hazardous Substances Data)

Usage

General Description

CIS-2-BENZYLAMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE is a chemical compound with the molecular formula C14H21NOCl. It is a hydrochloride salt of a compound that contains a benzylamine group attached to a cyclohexanol ring. This chemical is often used in pharmaceutical research and drug development due to its potential therapeutic properties. It may act as a central nervous system depressant and analgesic, and has been studied for its potential use in the treatment of pain, anxiety, and other neurological conditions. Additionally, it may also have applications in chemical synthesis and as a reagent in organic chemistry.

InChI:InChI=1/C14H21NO/c16-14-9-5-4-8-13(14)11-15-10-12-6-2-1-3-7-12/h1-3,6-7,13-16H,4-5,8-11H2/p+1/t13-,14-/m0/s1

Upstream product

• 13727-29-2 2-phenyl-4a,5,6,7,8,8a-hexahydro-4H-1,3-benzoxazine 
• 110-83-8 cyclohexene 
• 77612-17-0 N-benzyl-trans-2-aminomethyl-1-cyclohexanol 
• 100-46-9 benzylamine 
• 63301-31-5 trans-2-cyanocyclohexanol 
• 13727-29-2 cis-5,6-cyclohexylene-5,6-dihydro-2-phenyl-4H-1,3-oxazine 
• 6282-02-6 N-(hydroxymethyl)benzamide 
• 20617-32-7 cis-2-benzoylaminomethyl-1-cyclohexanol 
• 34453-05-9 N-Benzyl-trans-hexahydrosalicylamid 

Downstream Products

• 77612-20-5 E-N-benzyl-2-p-nitrophenyl-5,6-tetramethylenetetrahydro-1,3-oxazines 
• 77612-20-5 Z-N-benzyl-2-p-nitrophenyl-5,6-tetramethylenetetrahydro-1,3-oxazines 
• 77612-17-0 cis-N-benzyl-2-aminomethyl-1-cyclohexanol 

Relevant articles and documents

Amine-directed hydroboration: Scope and limitations

Iodine activation induces intramolecular hydroboration of homoallylic and bis-homoallylic amine boranes with good to excellent control of regiochemistry compared to control experiments using excess THF?BH3. Deuterium labeling and other evidence confirm that the iodine-induced hydroboration reaction of homoallylic amine boranes occurs via an intramolecular mechanism equivalent to the classical 4-center process and without competing retro-hydroboration. Longer carbon chain tethers result in lower regioselectivity, whereas the shorter tether in allylic amines results in a switch to dominant intermolecular hydroboration. Regioselectivity in THF?BH3 control experiments is higher for the allylic amine boranes compared to the iodine activation experiments, whereas the reverse is true for homoallylic amine borane activation.

trans-2-Cyanocycloalkanols: Versatile Synthons for Alicyclic cis- and trans-1,3-Amino Alcohols

From trans-2-hydroxycyclopentanecarbonitrile (1) and trans-2-hydroxycyclohexanecarbonitrile (2), a number of trans-2-aminomethylcycloalkanols are prepared by reductive alkylation.Inversion of trans-N-acylaminocycloalkanols by treatment with thionyl chlori

STEREOCHEMICAL STUDIES XXXVIII SATURATED HETEROCYCLES, XIV; SYNTHESIS AND CONFORMATIONAL ANALYSIS OF STEREOISOMERIC CIS- AND TRANS-TETRAMETHYLENETETRAHYDRO-N-METHYL- AND -N-BENZYL-1,3-OXAZINES

Cis and trans-2-methylaminomethyl- and -benzylaminomethyl-1-cyclohexanol (1-4), as well as cis- and trans-2-hydroxymethyl-1-methylamino- and -benzylamino-cyclohexane (5-8) were allowed to react with p-nitrobenzaldehyde to yield 2-p-nitrophenyl-3-methyl- a