77764-68-2

Upstream product

• 150-60-7 dibenzyl disulphide 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 33704-38-0 2-(benzylsulfinothioyl)isoindoline-1,3-dione 
• 1679-18-1 4-Chlorophenylboronic acid 
• 106-54-7 p-Chlorothiophenol 
• 5797-02-4 acetyl benzyl disulfide 
• 21700-74-3 (p-chlorophenyl)triethoxysilane 
• 100-44-7 benzyl chloride 
• 42106-43-4 N-p-nitrophenyl-p-chlorobenzenesulfenamide 
• 100-53-8 phenylmethanethiol 

Relevant academic research and scientific papers

Phthalimide-Carried Disulfur Transfer to Synthesize Unsymmetrical Disulfanes via Copper Catalysis

A versatile Cu-catalyzed cross-coupling reaction to various unsymmetrical disulfanes has been presented, from phthalimide-carried disulfur transfer reagents and commercially available boronic acids under mild and practical conditions. The method features the unprecedented use of phthalimide-carried disulfurating reagents (Harpp reagent) in cross-coupling chemistry and is highlighted by the broad substrate scopes, even applicable for the transfer of aryl-disulfur moieties (ArSS-). Notably, the robustness of this methodology is shown by the late-stage modification of bioactive scaffolds of coumarin, estrone, and captopril.

Asymmetric kinetic resolution of sulfides for the construction of unsymmetric sulfides and chiral 3,3-disubstituted oxindoles

A range of 3,3-disubstituted oxindoles accessed using para-quinone methides derived from isatins with thiols were used for the formation of unsymmetrical disulfides, and 3,3-disubstituted oxindoles with a chiral quaternary carbon center and unsymmetric di

Nucleophilic disulfurating reagents for unsymmetrical disulfides construction via copper-catalyzed oxidative cross coupling

Novel disulfuration was established via cross coupling between nucleophilic disulfurating reagent and arylsilane introducing two sulfur atoms in one step. This methodology was applied to synthesize various unsymmetrical disulfides under mild conditions via copper-catalyzed oxidative Hiyama-type cross coupling, providing a new pathway for disulfide synthesis. In addition, pH value of system displayed a key role in alcoholysis process.

Aryl-alkyl asymmetric persulfate compound, and synthesis method and application thereof

The invention discloses an aryl-alkyl asymmetric persulfate compound shown as a formula (3) and a synthesis method thereof. Arylboronic acid shown as a formula (I) and R2SSCOR3 shown as a formula (2) are used as reaction raw materials; under the effects of metal copper catalysts, reaction is performed to obtain the aryl-alkyl asymmetric persulfate compound. The method has the advantages that the reaction conditions are mild; the raw materials are low in cost and easy to obtain; the reaction operation is simple; the yield is higher; cheap metal is used as catalysts in the reaction process; economy and practicability are realized; the environment-friendly performance is achieved; reaction substrates can be easily prepared; after the reaction amplification, the reaction efficiency is high. The prepared aryl-alkyl asymmetric persulfate compound shown as the formula (3) and prepared by the method can be used for further synthesizing potential medicine compounds containing C-S bonds, such as benzyl (phenyl) thioether and benzyl (4-methoxy phenyl) thioether. The aryl-alkyl asymmetric persulfate compound and the synthesis method provided by the invention have the advantages of wide application prospects and practical value.

4'-NITROARENESULPHENANILIDES: THEIR USE IN THE SYNTHESIS OF UNSYMMETRICAL DISULPHIDES

The reaction of 4'-nitroarenesulphenanilides with thiols in the presence of boron trifluoride etherate can provide an effective route to unsymmetrical disulphides.

DISULFIDE INTERCHANGE REACTIONS BY SUPEROXIDE

Superoxide, which was produced by an electrochemical method, catalyzes instantaneously the interchange reaction of disulfides.The relationship between the half-wave potentials of disulfides and the amounts of superoxide required to complete the reaction w