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Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-methoxyquinazoline serves as a key building block in the synthesis of various drugs. Its unique structure and functional groups contribute to the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-4-methoxyquinazoline is utilized in the production of agrochemicals. Its chemical properties allow for the creation of compounds that can be used in pest control and crop protection, thereby enhancing agricultural productivity.
Used as a Medicinal Chemistry Intermediate:
Due to its demonstrated biological activities, 2-Chloro-4-methoxyquinazoline is employed as an intermediate in medicinal chemistry. It plays a crucial role in the design and synthesis of novel compounds with potential applications in treating various diseases and medical conditions.

Upstream product

• 67-56-1 methanol 
• 607-68-1 2,4-dichloroquinazoline 
• 124-41-4 sodium methylate 
• 91192-31-3 4-methoxy-quinazoline 1-oxide 
• 7791-25-5 sulfuryl dichloride 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 90417-37-1 4-methoxy-1H-quinazolin-2-one 

Downstream Products

• 59870-43-8 2-chloro-quinazolin-4-ylamine 
• 952443-52-6 1-((S)-3-(4-methoxyquinazolin-2-ylamino)pyrrolidin-1-yl)-2-(4-trifluoromethoxyphenyl)ethanone 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 101570-02-9 N-(4-methoxy-quinazolin-2-yl)-anthranilic acid methyl ester 
• 98324-40-4 (4-methoxy-quinazolin-2-yl)-phenyl-amine 
• 611-65-4 2,4-diethoxy-quinazoline 

Relevant academic research and scientific papers

Synthesis and Structure-Photophysics Evaluation of 2-N-Amino-quinazolines: Small Molecule Fluorophores for Solution and Solid State

2-N-aminoquinazolines were prepared by consecutive SNAr functionalization. X-ray structures display the nitrogen lone pair of the 2-N-morpholino group in conjugation with the electron deficient quinazoline core and thus representing electronic push-pull systems. 2-N-aminoquinazolines show a positive solvatochromism and are fluorescent in solution and in solid state with quantum yields up to 0.73. Increase in electron donor strength of the 2-amino substituent causes a red-shift of the intramolecular charge transfer (ICT) band (300–400 nm); whereas the photoluminescence emission maxima (350–450 nm) is also red-shifted significantly along with an enhancement in photoluminescence efficiency. HOMO-LUMO energies were estimated by a combination of electrochemical and photophysical methods and correlate well to those obtained by computational methods. ICT properties are theoretically attributed to an excitation to Rydberg-MO in SAC-CI method, which can be interpreted as n-π* excitation. 7-Amino-2-N-morpholino-4-methoxyquinazoline responds to acidic conditions with significant increases in photoluminescence intensity revealing a new turn-on/off fluorescence probe.

Synthesis of novel 1,5-disubstituted pyrrolo[1,2-: A] quinazolines and their evaluation for anti-bacterial and anti-oxidant activities

A new series of 1,5-disubstituted pyrrolo[1,2-a]quinazoline derivatives were prepared from 2-chloro-4-substituted quinazolines, propargyl alcohol, and secondary amines through novel multi-component reactions. These one-pot reactions, carried out in the presence of a palladium-copper catalyst, provide an efficient method for the synthesis of functionalized pyrrolo[1,2-a]quinazolines in good-to-high yields. A number of synthesized compounds were screened for their in vitro anti-bacterial activity against Gram-positive and Gram-negative bacteria using a well-diffusion method. Also the anti-oxidant activity of the products was evaluated using the DPPH (2,2-diphenyl-2-picrylhydrazyl) assays.

IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Imidazopyridine derivatives as JAK inhibitors

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Synthesis and evaluation on anticonvulsant and antidepressant activities of 5-alkoxy-tetrazolo[1,5-a]quinazolines

Several 5-alkoxy-tetrazolo[1,5-a]quinazoline derivatives have been synthesized by reacting 2,4-dichloroquinazoline with various phenols or aliphatic alcohol and then with sodium azide. The structures of these compounds have been confirmed by IR, MS,

AMINOPYRROLIDINE COMPOUND

Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.