77767-98-7

Basic information

• Product Name: 2-CHLORO-4-METHOXYQUINAZOLINE
• Synonyms: 2-CHLORO-4-METHOXYQUINAZOLINE;4-METHOXY-2-CHLOROQUINAZOLINE;Quinazoline, 2-chloro-4-methoxy-
• CAS NO: 77767-98-7
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.62
• Mol File: 77767-98-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 2-CHLORO-4-METHOXYQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHOXYQUINAZOLINE(77767-98-7)
• EPA Substance Registry System: 2-CHLORO-4-METHOXYQUINAZOLINE(77767-98-7)

Safety Data

• Hazardous Substances Data: 77767-98-7(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-methoxyquinazoline is a chemical compound with the molecular formula C9H7ClN2O. It is a white to off-white crystalline powder that is used in the production of pharmaceuticals and agrochemicals. 2-Chloro-4-methoxyquinazoline is a heterocyclic compound that contains a quinazoline ring system with a chlorine atom at position 2 and a methoxy group at position 4. It is commonly used as a building block in the synthesis of various drugs and organic compounds due to its versatile reactivity and functional groups. Additionally, it has been found to exhibit various biological activities, making it a valuable intermediate in the field of medicinal chemistry.

Upstream product

• 91192-31-3 4-methoxy-quinazoline 1-oxide 
• 90417-37-1 4-methoxy-1H-quinazolin-2-one 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 7791-25-5 sulfuryl dichloride 
• 607-68-1 2,4-dichloroquinazoline 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 59870-43-8 2-chloro-quinazolin-4-ylamine 
• 952443-52-6 1-((S)-3-(4-methoxyquinazolin-2-ylamino)pyrrolidin-1-yl)-2-(4-trifluoromethoxyphenyl)ethanone 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 101570-02-9 N-(4-methoxy-quinazolin-2-yl)-anthranilic acid methyl ester 
• 98324-40-4 (4-methoxy-quinazolin-2-yl)-phenyl-amine 
• 611-65-4 2,4-diethoxy-quinazoline 

Relevant articles and documents

Synthesis and Structure-Photophysics Evaluation of 2-N-Amino-quinazolines: Small Molecule Fluorophores for Solution and Solid State

2-N-aminoquinazolines were prepared by consecutive SNAr functionalization. X-ray structures display the nitrogen lone pair of the 2-N-morpholino group in conjugation with the electron deficient quinazoline core and thus representing electronic push-pull systems. 2-N-aminoquinazolines show a positive solvatochromism and are fluorescent in solution and in solid state with quantum yields up to 0.73. Increase in electron donor strength of the 2-amino substituent causes a red-shift of the intramolecular charge transfer (ICT) band (300–400 nm); whereas the photoluminescence emission maxima (350–450 nm) is also red-shifted significantly along with an enhancement in photoluminescence efficiency. HOMO-LUMO energies were estimated by a combination of electrochemical and photophysical methods and correlate well to those obtained by computational methods. ICT properties are theoretically attributed to an excitation to Rydberg-MO in SAC-CI method, which can be interpreted as n-π* excitation. 7-Amino-2-N-morpholino-4-methoxyquinazoline responds to acidic conditions with significant increases in photoluminescence intensity revealing a new turn-on/off fluorescence probe.

IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Synthesis and evaluation on anticonvulsant and antidepressant activities of 5-alkoxy-tetrazolo[1,5-a]quinazolines

Several 5-alkoxy-tetrazolo[1,5-a]quinazoline derivatives have been synthesized by reacting 2,4-dichloroquinazoline with various phenols or aliphatic alcohol and then with sodium azide. The structures of these compounds have been confirmed by IR, MS,