6677-96-9

Basic information

• Product Name: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-methanesulphonate
• Synonyms: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-methanesulphonate;cortisol 21-mesylate;Methanesulfonic acid 11β,17-dihydroxy-3,20-dioxopregn-4-en-21-yl ester;Einecs 229-714-2;Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-((methylsulfonyl)oxy)-, (11beta)-;11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-methanesulfonate;2-((8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl methanesulfonate
• CAS NO: 6677-96-9
• Molecular Formula: C₂₂H₃₂O₇S
• Molecular Weight: 440.55028
• EINECS: 229-714-2
• Product Categories: Glucuronides, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 6677-96-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-methanesulphonate(CAS DataBase Reference)
• NIST Chemistry Reference: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-methanesulphonate(6677-96-9)
• EPA Substance Registry System: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-methanesulphonate(6677-96-9)

Safety Data

• Hazardous Substances Data: 6677-96-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Cortisol (H714615) derivative. A glucocorticoid that augments the accumulation of α-lactalbumin in midpregnant rat mammary tissue cultured in the presence of insulin and prolactin.

Upstream product

• 50-23-7 HYDROCORTISONE 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1166864-60-3 C₂₇H₃₁F₃O₅ 
• 140209-96-7 C₆₄H₈₀N₂O₁₆S₂ 
• 434-02-6 21-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione 
• 77826-00-7 (8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2′-oxetane]-3,3′(2H)-dione 
• 641-77-0 21-deoxycortisol 
• 128887-42-3 21-aminoacetoxy-11β,17α-dihydropregn-4-ene-3,20-dione hydrochloride 
• 114967-88-3 β-(11β,17α-Dihydroxy-4-pregnene-3,20-dion-21-yl-21-thio)propionic acid 

Relevant articles and documents

Steroidal C-21 mercapto derivatives as dissociated steroids: Discovery of an inhaled dissociated steroid

A series of C-21 mercapto derivatives of hydrocortisone have been synthesized and evaluated in cell based transrepression and transactivation assays. The benzothiazole derivative, compound 6 not only showed a dissociated profile in vitro functional assays but also a pharmacological profile in a Brown-Norway rat therapeutic index model of asthma that dissociated side effects (thymolysis) while maintaining efficacy against pulmonary inflammation and lung function.

C-21 THIOETHERS AS GLUCOCORTICOID RECEPTOR AGONISTS

The present invention provides compounds of Formula (VII) and 11-keto analogs thereof, and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, and isomers of said compounds and said 11-keto analogs, having the general structure formula (VII): wherein L, R1, R2, R3, R4, and R5 are selected independently of each other and as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions. The novel compounds of the present invention possess useful pharmacological activity while having unexpectedly low systemic activiy. Thus, the compounds of the invention represent a safer alternative to those known glucocorticoids which have poor side-effect profiles.

SYNTHESIS OF 21-ESTERS OF HYDROCORTISONE WITH GLYCINE AND GLUTAMIC ACID AND STUDY OF THEIR PHARMACOLOGICAL ACTIVITY

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