6677-96-9

Upstream product

• 50-23-7 HYDROCORTISONE 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 77826-00-7 (8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2′-oxetane]-3,3′(2H)-dione 
• 114967-88-3 β-(11β,17α-Dihydroxy-4-pregnene-3,20-dion-21-yl-21-thio)propionic acid 
• 1166864-60-3 C₂₇H₃₁F₃O₅ 
• 128887-42-3 21-aminoacetoxy-11β,17α-dihydropregn-4-ene-3,20-dione hydrochloride 
• 140209-96-7 C₆₄H₈₀N₂O₁₆S₂ 
• 434-02-6 21-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione 
• 641-77-0 21-deoxycortisol 

Relevant academic research and scientific papers

Steroidal C-21 mercapto derivatives as dissociated steroids: Discovery of an inhaled dissociated steroid

A series of C-21 mercapto derivatives of hydrocortisone have been synthesized and evaluated in cell based transrepression and transactivation assays. The benzothiazole derivative, compound 6 not only showed a dissociated profile in vitro functional assays but also a pharmacological profile in a Brown-Norway rat therapeutic index model of asthma that dissociated side effects (thymolysis) while maintaining efficacy against pulmonary inflammation and lung function.

C-21 THIOETHERS AS GLUCOCORTICOID RECEPTOR AGONISTS

The present invention provides compounds of Formula (VII) and 11-keto analogs thereof, and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, and isomers of said compounds and said 11-keto analogs, having the general structure formula (VII): wherein L, R1, R2, R3, R4, and R5 are selected independently of each other and as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions. The novel compounds of the present invention possess useful pharmacological activity while having unexpectedly low systemic activiy. Thus, the compounds of the invention represent a safer alternative to those known glucocorticoids which have poor side-effect profiles.

Synthesis of new local anti-inflammatory thiosteroids based on antedrug concept

The synthesis and the in vitro pharmacological evaluation of a number of topical corticosteroid derivatives designed on the basis of the antedrug concept are reported.Three series of compounds were synthesized in which sulfur-containing amino acids were incorporated to the steroidal structure in the 21 position.Compounds of series I are diesters of cystine with the 21-hydroxyl groups of the corticosteroids, while series II and III contain 21-amino and 21-thio corticosteroid derivatives, respectively.The new compounds were less potent than the parent corticosteroidsin vitro.The 21-yl--S-acetylamino cysteine 13 was the most interesting compound of the series and is now under further evaluation. topical anti-inflammatory steroids / sulfur amino acids / corticosteroid activity