77890-89-2

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 109-86-4 2-methoxy-ethanol 
• 77890-81-4 [(E)-2-(3,4-Dihydro-2H-pyran-2-yl)-1-phenylsulfanyl-vinyl]-trimethyl-silane 
• 77890-82-5 [(Z)-2-(3,4-Dihydro-2H-pyran-2-yl)-1-phenylsulfanyl-vinyl]-trimethyl-silane 
• 100-73-2 acrolein dimer 
• 62762-44-1 lithium bis(trimethylsilyl)(phenylthio)methylide 

Downstream Products

• 85621-27-8 (2E,4E,11E,13E)-(6S,7S,10R)-7-(tert-Butyl-dimethyl-silanyloxy)-15-[4-chloro-3-methoxy-5-(methoxycarbonyl-methyl-amino)-phenyl]-9,9,10-trimethoxy-4,6,14-trimethyl-pentadeca-2,4,11,13-tetraenoic acid methyl ester 
• 82599-05-1 {5-[(2E,4E,11E)-(6R,9S,10S)-9-(tert-Butyl-dimethyl-silanyloxy)-6,7,7,13,13-pentamethoxy-2,10,12-trimethyl-trideca-2,4,11-trienyl]-2-chloro-3-methoxy-phenyl}-methyl-carbamic acid methyl ester 
• 91365-95-6 (E)-3-{(2R,3R)-3-[(6E,8E)-(1R,2R,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-acrylic acid methyl ester 
• 85621-22-3 (E)-3-{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-acrylic acid 
• 85621-28-9 (2E,4E,11E,13E)-(6S,7S,10R)-7-(tert-Butyl-dimethyl-silanyloxy)-15-(4-chloro-3-methoxy-5-methylamino-phenyl)-9,9,10-trimethoxy-4,6,14-trimethyl-pentadeca-2,4,11,13-tetraenoic acid 
• 82598-94-5 (2S,3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-3-methoxy-4-(4-methoxy-benzyloxy)-2-(2-methoxy-ethoxy)-tetrahydro-pyran 
• 82599-08-4 {(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol 
• 82599-15-3 (2R,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxirane-2-carbaldehyde 
• 82598-96-7 (3R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-benzenesulfonyl-ethoxy)-3,4,4-trimethoxy-tetrahydro-pyran 
• 82599-07-3 (2E,9E,11E)-(4S,5S,8R)-5-(tert-Butyl-dimethyl-silanyloxy)-13-(4-chloro-3-methoxy-5-methylamino-phenyl)-7,7,8-trimethoxy-2,4,12-trimethyl-trideca-2,9,11-trien-1-ol 
• 82598-98-9 Acetic acid (E)-(2R,5S,6R)-7-benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,3,3-trimethoxy-6,8-dimethyl-undec-9-enyl ester 
• 89874-07-7 (3R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-3,4,4-trimethoxy-2-(2-phenylsulfanyl-ethoxy)-tetrahydro-pyran 
• 89874-18-0 Acetic acid (E)-(2R,5S,6R)-7-benzenesulfonyl-5-hydroxy-2,3,3-trimethoxy-6,8-dimethyl-undec-9-enyl ester 
• 91365-89-8 (3R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-one 

Relevant academic research and scientific papers

SYNTHETIC STUDIES TOWARD MAYTANSINOIDS (2) A NEW STRATEGY BASED ON ASYMMETRIC INDUCTION BY HETEROCONJUGATE ADDITION OF METHYLLITHIUM ONTO PYRANOSYL HETERO-OLEFINS

The functionalized pyranosyl hetero-olefins 4a, 13 and 15 received a remarkable diastereoselective addition of methyllithium to form threo adducts, one of which was introduced into a possible synthetic intermediate as 3 for maytansine (1) along Scheme I.