779341-20-7

Basic information

• Product Name: 4'-AMINO-BIPHENYL-3-OL
• Synonyms: AKOS B025033;4'-AMINO-BIPHENYL-3-OL;ART-CHEM-BB B025033
• CAS NO: 779341-20-7
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22
• Mol File: 779341-20-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-AMINO-BIPHENYL-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-AMINO-BIPHENYL-3-OL(779341-20-7)
• EPA Substance Registry System: 4'-AMINO-BIPHENYL-3-OL(779341-20-7)

Safety Data

• Hazardous Substances Data: 779341-20-7(Hazardous Substances Data)

Usage

General Description

4'-Amino-biphenyl-3-ol, also known as 4-aminobiphenyl-3-ol or 4-Amino-2'-hydroxybiphenyl, is a chemical compound with the molecular formula C12H11NO. It is a derivative of biphenyl, and is commonly used in the synthesis of pharmaceuticals and organic compounds. 4'-Amino-biphenyl-3-ol is a white to off-white crystalline powder with a melting point range of 169-172°C. It is slightly soluble in water and soluble in organic solvents. The chemical is considered to have low toxicity, but it has been identified as a potential human carcinogen by the International Agency for Research on Cancer. It is important to handle 4'-Amino-biphenyl-3-ol with caution and use proper safety measures when working with this compound.

Upstream product

• 207287-79-4 3'-methoxy-[1,1'-biphenyl]-4-amine 
• 10365-98-7 3-methoxyphenylboronic acid 
• 106-40-1 4-bromo-aniline 
• 87199-18-6 3-hydroxyphenylboronic acid 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 779341-22-9 (3'-hydroxybiphenyl-4-yl)carbamic acid benzyl ester 
• 779341-23-0 cyclohexylcarbamic acid 4'-benzyloxycarbonylaminobiphenyl-3-yl ester 

Relevant articles and documents

3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations

Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H (RNase H) remains an unvalidated antiviral target. A major challenge of specifically targeting HIV RNase H arises from the general lack of selectivity over RT polymerase (pol) and integrase (IN) strand transfer (ST) inhibitions. We report herein the synthesis and biochemical evaluations of three novel 3-hydroxypyrimidine-2,4-dione (HPD) subtypes carefully designed to achieve selective RNase H inhibition. Biochemical studies showed the two subtypes with an N-1 methyl group (9 and 10) inhibited RNase H in low micromolar range without siginificantly inhibiting RT polymerase, whereas the N-1 unsubstituted subtype 11 inhibited RNase H in submicromolar range and RT polymerase in low micromolar range. Subtype 11 also exhibited substantially reduced inhibition in the HIV-1 INST assay and no significant cytotoxicity in the cell viability assay, suggesting that it may be amenable to further structure-activity relationship (SAR) for identifying RNase H inhibitors with antiviral activity.

Cyclohexylcarbamic acid 3′- or 4′-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: Synthesis, quantitative structure-activity relationships, and molecular modeling studies

Fatty acid amide hydrolase (FAAH) is a promising target for modulating endocannabinoid and fatty acid ethanolamide signaling, which may have important therapeutic potential. We recently described a new class of O-arylcarbamate inhibitors of FAAH, includin