207287-79-4

Basic information

• Product Name: 3'-METHOXY-BIPHENYL-4-YLAMINE HYDROCHLORIDE
• Synonyms: CHEMBRDG-BB 4005744;AKOS BAR-0139;3'-METHOXY-BIPHENYL-4-YLAMINE;3'-METHOXY-BIPHENYL-4-YLAMINE HYDROCHLORIDE;3'-METHOXY[1,1'-BIPHENYL]-4-AMINE;3'-METHOXY[1,1'-BIPHENYL]-4-AMINE HYDROCHLORIDE;TIMTEC-BB SBB007493;4-(3-Methoxyphenyl)aniline
• CAS NO: 207287-79-4
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 235.71
• Product Categories: Amines and Anilines
• Mol File: 207287-79-4.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 340.3 °C at 760 mmHg
• Flash Point: 166.3 °C
• Appearance: /
• Density: 1.1 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.33±0.10(Predicted)
• CAS DataBase Reference: 3'-METHOXY-BIPHENYL-4-YLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-METHOXY-BIPHENYL-4-YLAMINE HYDROCHLORIDE(207287-79-4)
• EPA Substance Registry System: 3'-METHOXY-BIPHENYL-4-YLAMINE HYDROCHLORIDE(207287-79-4)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 207287-79-4(Hazardous Substances Data)

Usage

General Description

3'-Methoxy-Biphenyl-4-ylamine Hydrochloride is a chemical compound which belongs to the category of Organic compounds known as diarylethers. It is composed of the biphenyl structural unit which includes two benzene rings connected by a single bond, an amino group (-NH2) attached to the 4 position, and a methoxy group (-OCH3) substituted at the 3' position. The hydrochloride refers to the presence of a hydrochloric acid component, which gives the compound its acidic property. This chemical may be used in various applications in the field of organic chemistry such as synthesis and pharmaceutical research. However, safety precautions need to be taken as it can be harmful if swallowed, inhaled or comes in contact with skin.

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Downstream Products

• 1360630-31-4 N-(3'-methoxybiphenyl-4-yl)-2-naphthamide 
• 1360630-53-0 N-(3'-methoxybiphenyl-4-yl)naphthalene-2-sulfonamide 
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• 1360630-42-7 6-methoxy-N-(3'-methoxybiphenyl-4-yl)-2-naphthamide 
• 1360630-38-1 6-cyano-N-(3'-methoxybiphenyl-4-yl)-2-naphthamide 
• 1360630-33-6 N⁽²⁾-(3'-methoxybiphenyl-4-yl)naphthalene-2,6-dicarboxamide 
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• 779341-23-0 cyclohexylcarbamic acid 4'-benzyloxycarbonylaminobiphenyl-3-yl ester 
• 779341-22-9 (3'-hydroxybiphenyl-4-yl)carbamic acid benzyl ester 
• 779341-20-7 4'-amino-1,1'-biphenyl-3-ol 

Relevant articles and documents

Bifunctional Naphtho[2,3- d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects in Vitro and in Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production

Human dihydroorotate dehydrogenase (hDHODH) is an attractive target for cancer therapy. Based on its crystal structure, we designed and synthesized a focused compound library containing the structural moiety of 1,4-benzoquinone, which possesses reactive oxygen species (ROS) induction capacity. Compound 3s with a naphtho[2,3-d][1,2,3]triazole-4,9-dione scaffold exhibited inhibitory activity against hDHODH. Further optimization led to compounds 11k and 11l, which inhibited hDHODH activity with IC50 values of 9 and 4.5 nM, respectively. Protein-ligand cocrystal structures clearly depicted hydrogen bond and hydrophobic interactions of 11k and 11l with hDHODH. Compounds 11k and 11l significantly inhibited leukemia cell and solid tumor cell proliferation and induced ROS production, mitochondrial dysfunction, apoptosis, and cell cycle arrest. Nanocrystallization of compound 11l displayed significant in vivo antitumor effects in the Raji xenograft model. Overall, this study provides a novel bifunctional compound 11l with hDHODH inhibition and ROS induction efficacy, which represents a promising anticancer lead worthy of further exploration.

COMPOUNDS USEFUL IN THE TREATMENT OF DISORDERS ASSOCIATED WITH MUTANT RAS

The present invention relates to compounds of Formula I as defined herein, and salts and solvates thereof. (I) The present invention also relates to pharmaceutical compositions comprising compounds of Formula (I), and to compounds of Formula (I) for use i

One-Pot Palladium-Catalyzed Cross-Coupling Treble of Borylation, the Suzuki Reaction and Amination

A methodology for a sequential palladium-catalyzed cross-coupling procedure consisting of borylation, the Suzuki reaction and amination has been developed for the assembly of molecules with multi-aryl backbones. The linchpin of this development is the meta-terarylphosphine ligand, Cy*Phine, which has been employed as an air- and moisture-stable precatalyst, Pd(Cy*Phine)2Cl2, to improve the efficiency of one-pot borylation–Suzuki reactions. Additionally, the reactivity of the Pd-Cy*Phine system could be tuned to furnish a one-pot, borylation–Suzuki reaction–amination (BSA) cross-coupling treble. The methodology successfully integrated complementary conditions for three distinctly different and modular reactions. Average yields of 74–94% could be achieved for each segment that cumulatively afforded 50–84% yield over the entire three-step sequence in a single pot. (Figure presented.).