77973-25-2 Usage
General Description
1-(2-DIMETHYLAMINOMETHYL-4-METHOXY-PHENYL)-ETHANONE is a chemical compound with the molecular formula C12H17NO2. It is also known as 4'-Methoxy-1-(2-(dimethylamino)methyl)acetophenone and is used in the synthesis of pharmaceuticals and organic compounds. 1-(2-DIMETHYLAMINOMETHYL-4-METHOXY-PHENYL)-ETHANONE contains a benzene ring with a methoxy group and a dimethylamino group attached to it, as well as a ketone functional group. It is a pale yellow liquid with a characteristic odor and is commonly used as a reagent in chemical reactions and as an intermediate in the production of various organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 77973-25-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,9,7 and 3 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77973-25:
(7*7)+(6*7)+(5*9)+(4*7)+(3*3)+(2*2)+(1*5)=182
182 % 10 = 2
So 77973-25-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO2/c1-9(14)12-6-5-11(15-4)7-10(12)8-13(2)3/h5-7H,8H2,1-4H3
77973-25-2Relevant articles and documents
Cationic chalcone antibiotics. Design, synthesis, and mechanism of action
Nielsen, Simon F.,Larsen, Mogens,Boesen, Thomas,Sch?nning, Kristian,Kromann, Hasse
, p. 2667 - 2677 (2007/10/03)
This paper describes how the introduction of "cationic" aliphatic amino groups in the chalcone scaffold results in potent antibacterial compounds. It is shown that the most favorable position for the aliphatic amino group is the 2-position of the B-ring, in particular in combination with a lipophilic substituent in the 5-position of the B-ring. We demonstrate that the compounds act by unselective disruption of cell membranes. Introduction of an additional aliphatic amino group in the á-ring results in compounds that are selective for bacterial membranes combined with a high antibacterial activity against both Gram-positive and -negative pathogens. The most potent compound in this study (78) has an MIC value of 2 μM against methicillin resistant Staphylococus aureus.
