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Usage

Uses

Used in Pharmaceutical Research and Development:
2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester is utilized as a reagent in organic synthesis and serves as a building block in the production of pharmaceuticals. Its role in this industry is pivotal for the development of new drugs, particularly those targeting inflammation and pain relief.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester is employed as a versatile reagent. It contributes to the formation of various complex organic molecules, facilitating the synthesis of a wide range of chemical products.
Used in Anti-Inflammatory and Analgesic Applications:
2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester is used as a potential anti-inflammatory and pain-relieving agent. Its properties make it a candidate for research into new treatments for conditions characterized by inflammation and pain, offering a promising avenue for therapeutic development.
Used in Safety and Handling Protocols:
Given its potential to cause irritation, 2-(1-Methyl-2-pyrrolidinylidene)-Acetic acid ethyl ester is also used in the development of safety and handling protocols within laboratories and industries where it is synthesized or utilized. This ensures that personnel are protected from its adverse effects, emphasizing the importance of proper safety measures during its use.

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 25355-40-2 3,4-dihydro-1-methyl-2-(methylthio)-5H-pyrrolium iodide 
• 35116-15-5 Dibasic magnesium salt of ethyl hydrogen malonate 
• 105-36-2 ethyl bromoacetate 
• 39650-82-3 2,2-dimethoxy-1-methylpyrrolidine 
• 10441-57-3 1-methyl-pyrrolidine-2-thione 
• 117028-40-7 O-methyl-N-methylpyrrolidonium methylsulfate 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 144151-97-3 (E)-2-[1-Methyl-pyrrolidin-(2E)-ylidene]-3-oxo-5-phenyl-pent-4-enoic acid ethyl ester 

Relevant academic research and scientific papers

Lactam acetals : Part XXIV reaction with activated haloalkyl compounds with and without zinc

Reaction of 2-alkoxyimmonium methosulfates (2), and of lactam acetals (3) derived therefrom, with α-haloesters in presence of zinc (Reformatsky condition) yielded N-alkyl-2-(α-alkyl-α-alkoxycarbonyl)methylene-l-azacycloalkanes (6), while reaction of 3 with α-haloesters without zinc gave 3-alkoxycarbonylmethyl-l-azacycloalkane-2-one (5). Similar reaction of 2 and 3 with 4-bromoethylquinolin-2-one (4) in presence of zinc gave N-alkyl-2-[4-(2-oxoquinolyl)methylene]-1-azacycloalkanes (7), a key intermediate for the synthesis of antimalarial quinoline-4-methanols.

Synthesis of Hexahydroindol-6-ones by Cycloacylation of Vinylogous Urethanes

The title compounds were prepared by variations of a route in which the principal stages include conversion of N-substituted pyrrolidine-2-thiones 6 into vinylogous urethanes 10, which undergo subsequent cycloacylation.A related approach that uses a Robin

Synthesis in the Diazasteroid Group. XVIII. Syntheses of the 9,17-Diazasteroid System

A 9,17-diazasteroid system, I, was synthesized from an aminoester, III, and cyclohexanone.Unfortunately the yield was poor.Another 9,17-diazasteroid system, II, was prepared from the condensation product, XVa, of quinoline N-oxide with an active methine compound, IV.Thus, XVa was hydrolyzed, followed by decarboxylation, reduction and cyclization.The yield in each step to II was moderate.Keywords- azasteroid; diazasteroid; quinoline N-oxide; cyclization; Pictet-Spengler reaction; active methylene compound; pyrrolopyridine; quinolylpyrrolidine

Methods for Converting N-Alkyl Lactams to Vinylogous Urethanes and Vinylogous Amides via (Methylthio)alkylideniminium Salts

Treatment of enolizable (methylthio)alkylideniminium salts with active methylene compounds under basic conditions gives Knoevenagel-type adducts in excellent yields.Attempts to convert several of these adducts to vinylogous urethanes and vinylogous amides met with varied success.One-pot preparations of vinylogous urethanes and vinylogous amides from (methylthio)alkylideniminium salts and selected active methylene compounds are also described.