78167-68-7

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate is used as a solvent in the pharmaceutical industry for its ability to dissolve a wide range of substances, facilitating the manufacturing process of various medications.
Used in Petrochemical Industry:
In the petrochemical sector, Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate serves as a solvent, playing a crucial role in processes that require the dissolution of specific petrochemical compounds.
Used in Electronics Manufacturing:
The electronics manufacturing industry utilizes Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate as a solvent for its effectiveness in dissolving certain materials used in the production of electronic components.
Used in Organic Synthesis:
Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate is used as a reactant in organic synthesis, contributing to the creation of new chemical compounds for various applications.
Used as a Cleaning Agent:
This chemical is employed as a cleaning agent due to its capacity to dissolve and remove contaminants, making it useful in various cleaning processes across different industries.
It is important to handle Methyl 2-(1-Methyl-2-pyrrolidylidene)acetate with care, as it can pose health risks if not used properly, underscoring the need for proper safety measures during its application.

Upstream product

• 104165-16-4 N-Methyl-2-pyrrolidinylidenemalonic anhydride 
• 86208-87-9 (2,2-dimethyl-5-(1-methylpyrrolidin-2-ylidene)-1,3-dioxane-4,6-dione) 
• 51849-20-8 methyl 3-oxo-5-(phenylthio)pentanoate 
• 10441-57-3 1-methyl-pyrrolidine-2-thione 
• 67-56-1 methanol 
• 104165-17-5 (1-Methyl-pyrrolidin-2-ylidene)-ethenone 
• 124-41-4 sodium methylate 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 2033-24-1 cycl-isopropylidene malonate 
• 25355-40-2 3,4-dihydro-1-methyl-2-(methylthio)-5H-pyrrolium iodide 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 51856-76-9 methyl 2-(1-methylpyrrolidin-2-yl)acetate 

Relevant academic research and scientific papers

Novel process for preparing 1-methyl-2-(2-hydroxyethyl)pyrrolidine

The present invention relates to a method for synthesizing 1-methyl-2-(2-hydroxyethyl)pyrrolidine, which is useful as an intermediate of a pharmaceutical. More specifically, the present invention relates to a novel synthesis method which uses metal borohydride as a reducing agent in a process of manufacturing 1-methyl-2-(2-hydroxyethyl)pyrrolidine, which is a target substance, from methyl (2E/Z)-2-(1-methylpyrrolidinyridin-2-ylidene)acetate, wherein the methyl (2E/Z)-2-(1-methylpyrrolidinyridin-2-ylidene)acetate is reduced in two stages sequentially, thereby being able to obtain the target substance with a safe process and cheap cost compared to an existing method.COPYRIGHT KIPO 2020

An efficient process of preparation of 1-methyl-2-(2-hydroxyethyl)pyrrolidine for production in ton scale

The present invention relates to a safe, simple and novel manufacturing method of 1-methyl-2-(2-hydroxyethyl)pyrrolidine as a drug medium, capable of mass production. 1-methyl-2-(2-hydroxyethyl)pyrrolidine can be manufactured by: reducing a double bond into a single bond through hydrogenation reaction in the presence of palladium on carbon (Pd on C) catalyst, and sequentially reducing an ester group into an alcohol group with a reducing agent such as NaBH_4 or LiBH_4; reducing a double bond and an ester group at a single reaction at the same time; or performing enantioselective hydrogenation of allylic alcohol with a chiral catalyst.

The efficient process for preparation of methyl (2)-(1-methyl-2-pyrrolidinylidene)acetate

The present invention relates to an excellent method of a production process, which is capable of lowering production costs due to yield improvement, reduction in generating wastewater and waste fluid, and reduction in processing time, regarding a mass production of methyl-(2)-(1-methyl-2-pyrrolidinylidene)acetate in a chemical formula 3 which is an intermediate of 1-methyl-2-(2-hydroxyethyl)pyrrolidin as a useful intermediate of a medical substance in a chemical formula 4 of a synthesis process in a reaction formula 1.COPYRIGHT KIPO 2015

Synthesis of hexahydroindol-6-ones by reaction of 2-methylthiopyrrolinium salts with Nazarov reagents

The title compounds 6-8 were prepared by variations of a route commencing with base-promoted condensation of N-substituted 2-methylthio-Δ1-pyrrolinium iodides 2 with Nazarov and related reagents, followed by further manipulation of substituted enamines 11-14.

An Efficient Synthesis of Acetylated Bicyclic Hydroxypyrroles from Cyclic Lactams via Flash-Vacuum Pyrolysis of Meldrum's Acid Derivatives

The title compounds 9 were synthesized in three steps from cyclic lactams 2.After treatment of 2a-h with phosgene followed by the addition of Meldrum's acid to the chloroiminium chloride intermediates 3a-h, derivatives 4a-h were isolated in good yields.Compounds 4a-g were quantitatively converted to bicyclic enaminones 7a-g by flash-vacuum pyrolysis in the temperature range 480-600 deg C.In contrast, 4h provided 8h, the hydroxyprrole tautomer of 7h.The reaction takes place through the initial formation of (aminomethylene)ketenes 5a-h followed by a 1,4-hydrogen migration from the carbon adjacent to the nitrogen atom to the central carbon of the cumulenone.The lower temperature (480 deg C) needed for benzyl and N-carboalkoxy derivatives 4e-h in comparison with N-alkyl derivatives 4a-d (600 deg C) is correlated with gas-phase acidity of the migrating hydrogen atom.The hydroxypyrroles 8a-g, tautomers of 7a-g (78), were trapped with acetic anhydride, affording O-acetylated bicyclic hydroxypyrroles 9a-g.

A Stable Methyleneketene and the Stepwise Fragmentation of Meldrum's Acids

Mild flash vacuum pyrolysis of the Meldrum's acid derivative (3) gives the first example of a methylenemalonic anhydride (4), which decarboxylates in solution to give the first isolable methyleneketene (5); the structures are supported by (13)C n.m.r. spectra and chemical reactions.

Methods for Converting N-Alkyl Lactams to Vinylogous Urethanes and Vinylogous Amides via (Methylthio)alkylideniminium Salts

Treatment of enolizable (methylthio)alkylideniminium salts with active methylene compounds under basic conditions gives Knoevenagel-type adducts in excellent yields.Attempts to convert several of these adducts to vinylogous urethanes and vinylogous amides met with varied success.One-pot preparations of vinylogous urethanes and vinylogous amides from (methylthio)alkylideniminium salts and selected active methylene compounds are also described.