782-87-6

Upstream product

• 111-94-4 3,3'-Iminodipropionitrile 
• 100-44-7 benzyl chloride 
• 620-05-3 iodomethylbenzene 
• 107-13-1 acrylonitrile 
• 100-46-9 benzylamine 
• 100-39-0 benzyl bromide 
• 706-03-6 3-(benzylamino)propionitrile 

Downstream Products

• 1555-71-1 N1-(3-amino-propyl)-N1-benzyl-propane-1,3-diamine 
• 66128-33-4 N,N-bis(3-(N,N-bis(3-aminopropyl)amino)propyl)benzylamine 
• 66128-32-3 3-[[3-(benzyl-{3-[bis-(2-cyano-ethyl)-amino]-propyl}-amino)-propyl]-(2-cyano-ethyl)-amino]-propionitrile 
• 14247-04-2 4-amino-1-benzyl-1.2.5.6-tetrahydropyridine-3-carbonitrile 
• 881693-44-3 N,N'-bis(p-bromobenzenesulfonyl)bis(3-aminopropyl)benzylamine 
• 881693-48-7 N,N'-bis(m-nitrobenzenesulfonyl)bis(3-aminopropyl)benzylamine 
• 881693-47-6 N,N'-bis(o-nitrobenzenesulfonyl)bis(3-aminopropyl)benzylamine 
• 881693-46-5 N,N'-bis(p-butoxymethylbenzenesulfonyl)bis(3-aminopropyl)benzylamine 
• 47771-56-2 N⁴-benzyl-N¹,N⁷-ditosyl-4-aza-1,7-heptanediamine 
• 47741-42-4 N,N'-bis(benzenesulfonyl)bis(3-aminopropyl)benzylamine 
• 14205-01-7 N,N'-bis(p-nitrobenzenesulfonyl)bis(3-aminopropyl)benzylamine 
• 182316-34-3 9-benzyl-3-methylene-1,5-bis(benzenesulfonyl)-1,5,9-triazacyclododecane 
• 471867-02-4 9-Benzyl-1,5-bis-(4-bromo-benzenesulfonyl)-3-methylene-1,5,9-triaza-cyclododecane 
• 182316-06-9 3-methylene-1,5-bis(4-methylbenzenesulfonyl)-1,5,9-triazacyclododecane 

Relevant academic research and scientific papers

Green synthesis of Ag@Au bimetallic regenerated cellulose nanofibers for catalytic applications

The green synthesis of nanocomposites has attracted huge consideration in recent years due to its positive environmentally friendly impact. The present study reports the first bimetallic Ag-Au cellulose nanofiber composite (Ag@Au/CNCs) prepared via a very simple green preparation method. An aqueous leaves extract of Moringa oleifera was used to obtain the bimetallic Ag@Au/CNC nanocomposite. High-resolution transmission electron microscopy (HRTEM) observations revealed the successful formation of triangle, hexagonal, and spherical shapes of well-combined Ag-Au nanoparticles on the regenerated cellulose nanofiber surface. Further, the formation of Au-Ag bimetallic nanostructures was confirmed by X-ray photoelectron spectroscopy (XPS) and X-ray crystallography (XRD) results. The resultant bimetallic Ag@Au/CNC catalyst was found to perform remarkably well in the reduction of nitrophenols. The bimetallic Ag@Au/CNC catalyst gave excellent kapp values of 15.59 and 22.83 × 10-3 s-1 for the 2- A nd 4-nitrophenol reduction process, respectively. To our delight, the Ag@Au/CNC catalyst was found to perform well in the aza-Michael reaction. The catalytic activity of Ag@Au/CNCs was compared with mono-metallic Ag/CNCs, Au/CNCs, and other reported catalysts. Based on the results obtained, the high synergy of Ag@Au/CNCs was explained. A possible mechanism is proposed for the Ag@Au/CNC-catalyzed nitrophenol reduction and aza-Michael reactions.

Cultivation of a Cu/HMPC catalyst from a hyperaccumulating mustard plant for highly efficient and selective coupling reactions under mild conditions

Cu-containing activated carbon (eco-catalyst, Cu/HMPC, where 'C' defines 'carbon') was derived from a metal-hyperaccumulating mustard plant (HMP) by a simple chemical activation method. Transmission electron microscopy/selected area diffraction (HRTEM/SAED) results revealed that the Cu/HMPC has mainly three types of morphology [sheet-like morphology (2D), hollow-spheres (3D) and needle-like structures (1D)] which are interconnected. HRTEM-SAED, Raman and X-ray photoelectron spectroscopy (XPS) results confirmed the existence of Cu oxide species in Cu/HMPC. Content of Cu in Cu/HMPC was determined to be 1.03 wt%. The quality of graphitization in Cu/HMPC was discussed by using Raman and XRD results. The BET surface area of Cu/HMPC was determined to be 620.8 m2 g-1. The Cu/HMPC actively transformed a wide range of amines to imines under very mild reaction conditions. The catalyst Cu/HMPC gave products in excellent yields (98-61%) with very high TON/TOF values (1512/339-833/35 h-1). To the best of our knowledge, this is the most efficient Cu-based heterogeneous eco-catalyst for the synthesis of imines among those reported to date. The Cu can be recovered from used Cu/HMPC by a simple HCl treatment. Versatility, heterogeneity and reusability of Cu/HMPC were tested. A possible mechanism has been proposed.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Unsymmetrical cyclotriazadisulfonamide (CADA) compounds as human CD4 receptor down-modulating agents

Cyclotriazadisulfonamide (CADA) inhibits HIV at submicromolar levels by specifically down-modulating cell-surface and intracellular CD4. The specific biomolecular target of CADA compounds is unknown, but previous studies led to an unsymmetrical binding model. To test this model, methods were developed for effective synthesis of diverse, unsymmetrical CADA compounds. A total of 13 new, unsymmetrical target compounds were synthesized, as well as one symmetrical analogue. The new compounds display a wide range of potency for CD4 down-modulation in CHO-CD4-YFP cells. VGD020 (IC50 = 46 nM) is the most potent CADA compound discovered to date, and VGD029 (IC50 = 730 nM) is the most potent fluorescent analogue. Structure-activity relationships are analyzed from the standpoint of additive or nonadditive energy effects of different substituents. They appear to be consistent with the zipper-type mechanism in which entropy costs are reduced for additional stabilizing interactions between the small molecule and its protein target.

Convergent synthesis of polynitrile and/or polyamine dendrimers through hydroaminomethylation and Michael addition

A general concept for a versatile convergent synthesis ofpolynitrile and/or polyamine dendrimers has been developed by applying Voegtle's procedure in combination with thetandem hydroformylation/reductive amination sequence, known as hydroaminomethylation

Synthesis of dendritic tryptophan derivatives and investigation on dendritic effects of their fluorescence and reactivity

Two series of dendritic tryptophan derivatives have been synthesized and characterized, their emission spectra in different solvents and the reactivity of tryptophan were investigated and compared. There was a progressive shielding effect of the tryptophan in the emissive wavelengths of dendrimers increased with the size or generation of the dendritic shell.

An effective aza-michael addition of aromatic amines to electron-deficient alkenes in alkaline Al2O3

Aza-Michael addition of aromatic or aliphatic amines with various electron-deficient alkenes was performed using alkaline Al2O 3 as solid media at room temperature afforded the corresponding Michael addition products in good to excellent yields.The alkaline Al 2O3 can be easily recovered and reused.

Aqueous aza-michael reaction of conjugated alkenes: Toward spermine

An aqueous aza-Michael reaction is efficiently achieved with excellent conversions without any additives. The method works very well on a molar scale with selectively for aliphatic amines. An intermediate for spermine is also made by this green process.

POLYAMINE DERIVATIVE AND POLYOL DERIVATIVE

A novel polyamine derivative, or polyol derivative, having a piperidylaminotriazine skeleton, salts of such compounds, a process for producing them, an organic material stabilizer comprising any of such compounds, a method of stabilizing an organic materi

Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues

HIV attachment via the CD4 receptor is an important target for developing novel approaches to HIV chemotherapy. Cyclotriazadisulfonamide (CADA) inhibits HIV at submicromolar levels by specifically down-modulating cell-surface and intracellular CD4. An effective five-step synthesis of CADA in 30% overall yield is reported. This synthesis has also been modified to produce more than 50 analogues. Many tail-group analogues have been made by removing the benzyl tail of CADA and replacing it with various alkyl, acyl, alkoxycarbonyl and aminocarbonyl substituents. A series of sidearm analogues, including two unsymmetrical compounds, have also been prepared by modifying the CADA synthesis, replacing the toluenesulfonyl sidearms with other sulfonyl groups. Testing 30 of these compounds in MT-4 cells shows a wide range of CD4 down-modulation potency, which correlates with ability to inhibit HIV-1. Three-dimensional quantitative structure-activity relationship (3D-QSAR) models were constructed using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) approaches. The X-ray crystal structures of four compounds, including CADA, show the same major conformation of the central 12-membered ring. The solid-state structure of CADA was energy minimized and used to generate the remaining 29 structures, which were similarly minimized and aligned to produce the 3D-QSAR models. Both models indicate that steric bulk of the tail group, and, to a lesser extent, the sidearms mainly determine CD4 down-modulation potency in this series of compounds.