78210-51-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(1H-Pyrrol-1-ylmethyl)pyridine is used as a key intermediate in the synthesis of various pharmaceuticals due to its ability to participate in diverse chemical reactions such as alkylation, acylation, and oxidation. This leads to the production of a broad spectrum of derivatives with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(1H-Pyrrol-1-ylmethyl)pyridine is utilized as a precursor in the creation of compounds with pesticidal properties, leveraging its reactivity to form a variety of derivatives that can be employed in crop protection and management.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-(1H-Pyrrol-1-ylmethyl)pyridine is used for the preparation of complex organic molecules and heterocyclic compounds, contributing to the advancement of chemical research and the development of new materials with specialized properties.
Used in Research and Development:
2-(1H-Pyrrol-1-ylmethyl)pyridine is also used in research settings to explore its potential pharmacological effects and biological activity, with ongoing studies aiming to uncover its full range of applications and therapeutic potential.

InChI:InChI=1/C10H10N2/c1-2-6-11-10(5-1)9-12-7-3-4-8-12/h1-8H,9H2

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 51-35-4 4R-4-hydroxyproline 
• 60032-62-4 2-[(1-Pyrrolidinyl)methyl]pyridine 
• 55401-97-3 2-(Bromomethyl)pyridine 

Downstream Products

• 1198351-43-7 4-[1-(pyridyn-2-ylmethyl)pyrrol-2-yl]benzonitryle 

Relevant academic research and scientific papers

An elegant protocol for the synthesis of N-substituted pyrroles through C-N cross coupling/aromatization process using CuFe2O4 nanoparticles as catalyst under ligand-free conditions

A simple and efficient, ligand-free C-N cross-coupling of aryl halides/benzyl bromides with trans-4-hydroxy-l-proline has been developed to produce aromatized N-substituted pyrroles, using a catalytic amount of magnetically separable and recyclable CuFe2O4 nanoparticles, in the presence of Cs2CO3 in DMSO at 100 °C.

Organic synthesis via magnetic attraction: Benign and sustainable protocols using magnetic nanoferrites

Magnetic nano-catalysts have been prepared using simple modification of iron ferrites. The nm size range of these particles facilitates the catalysis process, as an increased surface area is available for the reaction; the easy separation of the catalysts by an external magnet and their recovery and reuse are additional beneficial attributes. Glutathione bearing nano-ferrites have been used as organocatalysts for the Paal-Knorr reaction and homocoupling of boronic acids. Nanoferrites, post-synthetically modified by ligands, were used to immobilize nanometals (Cu, Pd, Ru, etc.) which enabled the development of efficient, sustainable and green procedures for azide-alkynes-cycloaddition (AAC) reactions, C-S coupling, O-allylation of phenol, Heck-type reactions and hydration of nitriles.

A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-l-proline with aldehydes

An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-l-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.

O-Iodoxybenzoic acid (IBX): A versatile reagent for the synthesis of N-substituted pyrroles mediated by β-cyclodextrin in water

O-Iodoxybenzoic acid (IBX), a very mild and efficient hypervalent iodine(V) reagent, aromatizes diversely substituted 1-benzylpyrrolidines and N-substituted l-proline analogues to the corresponding substituted pyrroles in good to excellent yields under mild conditions mediated by β-cyclodextrin in water at room temperature. To the best of our knowledge, this is the first report on IBX, promoting complete aromatization leading to N-benzylpyrroles from the corresponding saturated five membered heterocyclic derivatives in water medium.

Trans-4-Hydroxy-l-proline: A novel starting material for N-alkylpyrroles synthesis

The reaction of aldehydes with trans-4-hydroxy-l-proline was studied for the first time, resulting in the formation of N-alkylpyrroles in good to excellent yields, via decarboxylation followed by redox isomerization under neutral conditions. The neutral c

Magnetic Nanoparticle-Supported Glutathione as a Sustainable Organocatalyst

This invention relates to the use of nano-organocatalysts, and, more specifically, to the use of magnetic nanomaterial-supported organocatalysts. It is an object of the present invention to provide “green” catalysts and protocols. According to one embodiment of the invention, a nano-organocatalyst in the form of a magnetic nanomaterial-supported organocatalyst is provided. According to other embodiments of the invention, glutathione and cysteine are provided as organocatalysts and magnetic nanomaterial-supported glutathione and magnetic nanomaterial-supported cysteine are provided for use as nano-organocatalysts. According to another embodiment of the invention, a method of using a recyclable magnetic nanomaterial-supported organocatalyst using a totally benign aqueous protocol, without using any organic solvent in the reaction or during the workup, is provided. According to a further embodiment of the invention, a recyclable magnetic nanomaterial-supported organocatalyst for various organocatalytic reactions, including but not limited to Paal-Knorr reactions, aza-Michael addition and pyrazole synthesis, is provided.

Nano-organocatalyst: magnetically retrievable ferrite-anchored glutathione for microwave-assisted Paal-Knorr reaction, aza-Michael addition, and pyrazole synthesis

Postsynthetic surface modification of magnetic nanoparticles by glutathione imparts desirable chemical functionality and enables the generation of catalytic sites on the surfaces of ensuing organocatalysts. In this article, we discuss the developments, unique activity, and high selectivity of nano-organocatalysts for microwave-assisted Paal-Knorr reaction, aza-Michael addition, and pyrazole synthesis. Their insoluble character coupled with paramagnetic nature enables easy separation of these nano-catalysts from the reaction mixture using external magnet, which eliminates the requirement of catalyst filtration.

Magnetic nanoparticle-supported glutathione: A conceptually sustainable organocatalyst

A conceptually novel nanoparticle-supported and magnetically recoverable organocatalyst has been developed, which is readily prepared from inexpensive starting materials in a truly sustainable manner; which catalyzes the Paal-Knorr reaction with high yield in pure aqueous medium that avoids the use of toxic organic solvents, even in the workup step.