78224-64-3

Basic information

• Product Name: (E)-8-methoxy-2-styrylquinoline
• Synonyms: (E)-8-methoxy-2-styrylquinoline
• CAS NO: 78224-64-3
• Molecular Weight: 261.323
• Mol File: 78224-64-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (E)-8-methoxy-2-styrylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-8-methoxy-2-styrylquinoline(78224-64-3)
• EPA Substance Registry System: (E)-8-methoxy-2-styrylquinoline(78224-64-3)

Safety Data

• Hazardous Substances Data: 78224-64-3(Hazardous Substances Data)

Upstream product

• 3033-80-5 8-methoxy-2-methylquinoline 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 
• 19490-87-0 7-methoxy-2-methylquinoline 
• 758640-21-0 N-Benzylaniline 
• 90-04-0 2-methoxy-phenylamine 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 

Downstream Products

• 1571-30-8 8-hydroxy-quinoline-2-carboxylic acid 
• 21141-35-5 8-methoxyquinoline-2-carboxylic acid 

Relevant articles and documents

Nickel-catalysed direct α-olefination of alkyl substituted N-heteroarenes with alcohols

Catalytic α-olefination of alkylheteroarenes with primary alcohols via dehydrogenative coupling is presented. A simple nickel catalyst system stabilised by readily available nitrogen ligands enables a series of interesting E-configured vinylarenes (confirmed by X-ray crystal-structure analysis) to be synthesised in good to excellent yields with olefin/alkane selectivity of >20:1. Hydrogen and water are generated as byproducts and quantitative determination of H2 was performed.

Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation

Here we report the synthesis and in vitro evaluation of 25 new quinolinyl analogues for α-synuclein aggregates. Three lead compounds were subsequently labeled with carbon-11 or fluorine-18 to directly assess their potency in a direct radioactive competitive binding assay ng both α-synuclein fibrils and tissue homogenates from Alzheimer's disease (AD) cases. The modest binding affinities of these three radioligands toward α-synuclein were comparable with results from the Thioflavin T fluorescence assay. However, all three ligand also showed modest binding affinity to the AD homogenates and lack selectivity for α-synuclein. The structure–activity relationship data from these 25 analogues will provide useful information for design and synthesis of new compounds for imaging α-synuclein aggregation.

Cobalt-catalyzed direct alkenylation of 2-methylquinolines with aldehydes via C(sp3)-H functionalization in water

The direct C(sp3)-H alkenylation of 2-methylquinolines with aldehydes as a simple methodology to afford 2-alkenylated quinolines is reported. In the presence of catalytic CoCl2 in water, the economically and ecologically sound transformation is proposed to proceed via the direct benzylic addition to the aldehyde followed by an elimination step to provide 2-alkenylated quinolines in good to excellent yield of up to 95%. Georg Thieme Verlag Stuttgart New York.