78252-11-6Relevant articles and documents
Design and synthesis of muscarinic acetylcholine receptor (mAChR) antagonist: pharmacophore-based screening and structure-based optimization
Ghorpade, RamaRao,Kumar, Deo,Nayak, Sabita,Acharya, Badri Narayan
, p. 1335 - 1347 (2019)
Abstract: This study describes screening of muscarinic acetylcholine receptors (mAChR) antagonist by pharmacophore modeling and optimization by molecular docking. A series of molecules was synthesized and evaluated for preliminary pharmacological activity
N-benzyl-N-aryl sulfonamide derivative as well as preparation and application thereof
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Paragraph 0155-0158, (2019/04/30)
The invention provides an N-Benzyl-N-Aryl sulfonamide derivative, wherein the N-Benzyl-N-Aryl sulfonamide derivatives include pharmaceutically acceptable salts and/or solvates thereof. The N-Benzyl-N-Aryl sulfonamide derivatives is obtained by condensatio
PROTEIN KINASE C INHIBITORS AND USES THEREOF
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Paragraph 00736; 00739; 00742, (2013/10/22)
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to ph
THERAPEUTIC CHROMONE COMPOUNDS
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, (2008/06/13)
Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B antagonists. Also provided herein are processes for making compounds of Formula (I) and intermediate compounds.
Therapeutic chroman compounds
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, (2008/06/13)
Provided herein is a compound represented by the Formula (I) wherein said compounds are useful for the treatment of migraine. Also provided are processes for the preparation of compounds of Formula (I) and intermediates.
Therapeutic heterocyclic compounds
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, (2008/06/13)
Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
AMIDE COMPOUNDS AND MEDICINAL USE THEREOF
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, (2010/01/31)
The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.
The Origins of the Dichotomy of Amine Effects in Aromatic Nucleophilic Substitution Reactions
Akpojivi, Raymond E.,Emokpae, Thomas A.,Hirst, Jack
, p. 443 - 450 (2007/10/02)
The reactions of 2-trifluoromethyl- amd 2-cyano-4-nitrofluoro-benzenes with piperidine, n-butylamine and benzylamine in acetonitrile are not base catalysed, but the reactions with morpholine are catalysed.In benzene, the reactions of the 2-cyano-substrate