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2-Morpholino-5-nitrobenzonitrile is a chemical compound characterized by the molecular formula C11H10N4O3. It is a derivative of nitrobenzonitrile, featuring a morpholine group attached at the 2-position on the benzene ring. 2-Morpholino-5-nitrobenzonitrile is recognized for its reactivity and is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Additionally, it finds applications in the production of dyes, pigments, and other industrial chemicals, making it a versatile component in chemical manufacturing processes.

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  • 78252-11-6 Structure
  • Basic information

    1. Product Name: 2-Morpholino-5-nitrobenzonitrile
    2. Synonyms: 2-Morpholino-5-nitrobenzonitrile;2-(4-Morpholinyl)-5-nitrobenzonitrile
    3. CAS NO:78252-11-6
    4. Molecular Formula: C11H11N3O3
    5. Molecular Weight: 233.22334
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 78252-11-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Morpholino-5-nitrobenzonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Morpholino-5-nitrobenzonitrile(78252-11-6)
    11. EPA Substance Registry System: 2-Morpholino-5-nitrobenzonitrile(78252-11-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 78252-11-6(Hazardous Substances Data)

78252-11-6 Usage

Uses

Used in Pharmaceutical Industry:
2-Morpholino-5-nitrobenzonitrile is utilized as a key intermediate in the synthesis of pharmaceuticals. Its unique structure allows it to be a building block for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Organic Chemistry:
In the realm of organic chemistry, 2-Morpholino-5-nitrobenzonitrile serves as a valuable intermediate for the synthesis of a range of organic compounds. Its reactivity and structural features make it suitable for various organic reactions, facilitating the creation of complex molecules.
Used in Dye and Pigment Production:
2-Morpholino-5-nitrobenzonitrile is employed in the production of dyes and pigments, where its chemical properties contribute to the color and stability of these products. Its use in this industry highlights its versatility and importance in creating a wide array of colorants for various applications.
Used in Industrial Chemicals:
2-Morpholino-5-nitrobenzonitrile also finds its place in the production of other industrial chemicals, where it may be used to enhance the properties of these chemicals or to serve as a component in their synthesis. Its role in this sector underscores its broad applicability across different areas of the chemical industry.
It is important to handle 2-Morpholino-5-nitrobenzonitrile with care due to its potential hazards, ensuring that safety protocols are followed to mitigate any risks associated with its reactivity.

Check Digit Verification of cas no

The CAS Registry Mumber 78252-11-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,2,5 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 78252-11:
(7*7)+(6*8)+(5*2)+(4*5)+(3*2)+(2*1)+(1*1)=136
136 % 10 = 6
So 78252-11-6 is a valid CAS Registry Number.

78252-11-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Morpholino-5-nitrobenzonitrile

1.2 Other means of identification

Product number -
Other names 2-morpholin-4-yl-5-nitrobenzonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78252-11-6 SDS

78252-11-6Relevant articles and documents

Design and synthesis of muscarinic acetylcholine receptor (mAChR) antagonist: pharmacophore-based screening and structure-based optimization

Ghorpade, RamaRao,Kumar, Deo,Nayak, Sabita,Acharya, Badri Narayan

, p. 1335 - 1347 (2019)

Abstract: This study describes screening of muscarinic acetylcholine receptors (mAChR) antagonist by pharmacophore modeling and optimization by molecular docking. A series of molecules was synthesized and evaluated for preliminary pharmacological activity

N-benzyl-N-aryl sulfonamide derivative as well as preparation and application thereof

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Paragraph 0155-0158, (2019/04/30)

The invention provides an N-Benzyl-N-Aryl sulfonamide derivative, wherein the N-Benzyl-N-Aryl sulfonamide derivatives include pharmaceutically acceptable salts and/or solvates thereof. The N-Benzyl-N-Aryl sulfonamide derivatives is obtained by condensatio

PROTEIN KINASE C INHIBITORS AND USES THEREOF

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Paragraph 00736; 00739; 00742, (2013/10/22)

This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to ph

THERAPEUTIC CHROMONE COMPOUNDS

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, (2008/06/13)

Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B antagonists. Also provided herein are processes for making compounds of Formula (I) and intermediate compounds.

Therapeutic chroman compounds

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, (2008/06/13)

Provided herein is a compound represented by the Formula (I) wherein said compounds are useful for the treatment of migraine. Also provided are processes for the preparation of compounds of Formula (I) and intermediates.

Therapeutic heterocyclic compounds

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, (2008/06/13)

Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

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, (2010/01/31)

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

The Origins of the Dichotomy of Amine Effects in Aromatic Nucleophilic Substitution Reactions

Akpojivi, Raymond E.,Emokpae, Thomas A.,Hirst, Jack

, p. 443 - 450 (2007/10/02)

The reactions of 2-trifluoromethyl- amd 2-cyano-4-nitrofluoro-benzenes with piperidine, n-butylamine and benzylamine in acetonitrile are not base catalysed, but the reactions with morpholine are catalysed.In benzene, the reactions of the 2-cyano-substrate

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