78252-12-7

Usage

Uses

Used in Pharmaceutical Industry:
5-amino-2-morpholin-4-ylbenzonitrile is used as a key intermediate in the synthesis of pharmaceutical drugs, primarily for the development of kinase inhibitors. Its unique structure allows for the creation of targeted therapies that can modulate specific cellular pathways, offering potential benefits in treating a range of diseases.
Used in Cancer Treatment:
In the field of oncology, 5-amino-2-morpholin-4-ylbenzonitrile is used as a potential anti-cancer agent. Its ability to inhibit specific kinases involved in cell proliferation and survival pathways makes it a promising candidate for the development of novel cancer therapies. Research is ongoing to explore its efficacy against various types of cancer.
Used in Anti-inflammatory Applications:
5-amino-2-morpholin-4-ylbenzonitrile is also being studied for its potential anti-inflammatory properties. Its ability to modulate inflammatory pathways could make it a valuable component in the development of new treatments for inflammatory diseases, such as arthritis and autoimmune disorders.
Used in Neurodegenerative Disease Treatment:
5-amino-2-morpholin-4-ylbenzonitrile has been investigated for its role in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's. Its potential to modulate kinase pathways involved in neuronal cell death and neuroinflammation makes it a promising candidate for the development of therapies aimed at slowing or halting the progression of these debilitating conditions.

InChI:InChI=1/C11H13N3O/c12-8-9-7-10(13)1-2-11(9)14-3-5-15-6-4-14/h1-2,7H,3-6,13H2

Upstream product

• 134604-07-2 2-bromo-5-nitrobenzonitrile 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 16588-15-1 2-chloro-5-nitro-benzamide 
• 78252-11-6 2-Morpholin-4-yl-5-nitro-benzonitrile 

Downstream Products

• 442548-68-7 6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (3-cyano-4-morpholin-4-yl-phenyl)-amide 
• 442548-87-0 6-Fluoro-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (3-cyano-4-morpholin-4-yl-phenyl)-amide 

Relevant academic research and scientific papers

N-benzyl-N-aryl sulfonamide derivative as well as preparation and application thereof

The invention provides an N-Benzyl-N-Aryl sulfonamide derivative, wherein the N-Benzyl-N-Aryl sulfonamide derivatives include pharmaceutically acceptable salts and/or solvates thereof. The N-Benzyl-N-Aryl sulfonamide derivatives is obtained by condensatio

VEGFR TYROSINE KINASE INHIBITORS

Novel compounds, their prodrugs, and the pharmaceutically acceptable salts as pharmaceutical compositions containing such compounds useful in treating certain diseases modulated by the inhibition of vascular endothelial growth factors (VEGFs) receptor tyrosine kinases are provided. In particular, compounds and compositions and the methods for the prophylaxis, management and treatment of cancers through the inhibition of VEGF receptor tyrosine kinases are provided.

PROTEIN KINASE C INHIBITORS AND USES THEREOF

This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to ph

THERAPEUTIC CHROMONE COMPOUNDS

Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B antagonists. Also provided herein are processes for making compounds of Formula (I) and intermediate compounds.

Therapeutic heterocyclic compounds

Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.