78259-61-7Relevant academic research and scientific papers
Calcium(II)-Catalyzed Aza-Piancatelli Reaction
Lebuf, David,Schulz, Emmanuelle,Gandon, Vincent
, p. 6464 - 6467 (2014)
The first examples of calcium-catalyzed aza-Piancatelli reactions between substituted 2-furylcarbinols and aniline derivatives are described. A variety of 4-aminocyclopentenones have been synthesized stereoselectively in high yields. The experimental proc
Divergent Synthesis of Dihydropyranone Stereoisomers via N-Heterocyclic Carbene Catalysis
Zhao, Changgui,Wang, Jian
, p. 1668 - 1672 (2019/02/19)
We recently developed a novel chiral N-heterocyclic carbene (NHC) catalyzed dynamic kinetic enantioselective acylation (DKEA) and dynamic kinetic diastereoselective acylation (DKDA) of Achmatowicz rearrangement products to generate useful intermediates for the further synthesis of carbohydrates. In this update, we describe a divergent NHC catalytic strategy for the stereoselective preparation of all four isomers starting from a common racemic precursor. The present report provides easy access to diverse optically pure dihydropyranones. (Figure presented.).
General Routes to 4-Methyl-2-substituted-furans: a Total Synthesis of Pleraplysillin-2, a Metabolite of the Sponge, Pleraplysilla spinifera
Knight, David W.,Rustidge, David C.
, p. 679 - 683 (2007/10/02)
A general approach to 4-methyl-2-substituted-furans is described in which 4-methyl-2-furyl-lithium is the key intermediate.Using this method, pleraplysillin-2, a sesquiterpenoid ester from the sponge Pleraplysilla spinifera, has been synthesised.An alternative, less efficient, route to this type of furan, via acyclic keto-epoxides, is also discussed.
