78296-37-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-6-phenylpyridine-2-carboxylic acid is used as a key intermediate in the synthesis of active pharmaceutical ingredients. Its versatile structure allows for the development of drugs with diverse therapeutic applications.
Used in Anti-cancer Agents:
In the field of oncology, 4-Hydroxy-6-phenylpyridine-2-carboxylic acid is utilized as a building block for the creation of anti-cancer agents. Its incorporation into drug molecules can contribute to the development of compounds that target and combat cancer cells, potentially leading to more effective treatments for various types of cancer.
Used in Antimicrobial Agents:
4-Hydroxy-6-phenylpyridine-2-carboxylic acid is also employed in the synthesis of antimicrobial agents. Its chemical properties enable the design of drugs that can effectively target and eliminate harmful microorganisms, contributing to the development of new antibiotics and antifungal medications.
Used in Anti-inflammatory Drugs:
In the realm of anti-inflammatory medications, 4-Hydroxy-6-phenylpyridine-2-carboxylic acid serves as a crucial component in the synthesis of drugs aimed at reducing inflammation and alleviating associated symptoms. Its presence in these medications can enhance their efficacy in treating various inflammatory conditions.

InChI:InChI=1/C12H9NO3/c14-9-6-10(8-4-2-1-3-5-8)13-11(7-9)12(15)16/h1-7H,(H,13,14)(H,15,16)

Upstream product

• 2397-77-5 Ethyl 4-oxo-6-phenyl-4H-pyran-2-carboxylate 
• 1083-01-8 4-oxo-6-phenyl-4H-pyrane-2-carboxylic acid 
• 1027-41-4 ethyl (E)-2,4-dioxo-6-phenylhex-5-enoate 
• 1154-90-1 Ethyl 5,6-dibromo-2,4-dioxo-6-phenylhexanoate 
• 7500-03-0 2-Methyl-6-phenyl-1,4-dihydropyridin-4-on 
• 26567-78-2 (Z)-4-(phenylamino)-3-penten-2-one 
• 123-54-6 acetylacetone 
• 412923-41-2 4-chloro-2-methyl-6-phenyl-pyridine 
• 85814-93-3 4-hydroxy-6-phenylpyridine-2-carboxamide 

Downstream Products

• 1191263-83-8 4-chloro-6-phenyl-pyridine-1-carboxylic acid ethyl ester 
• 1019929-28-2 4-((S)-3-methoxy-pyrrolidin-1-yl)-6-phenyl-pyridine-2-carboxylic acid 
• 1191264-25-1 4-(2-methoxy-ethoxy)-6-phenyl-pyridine-2-carboxylic acid 
• 1191264-30-8 6-phenyl-4-(tetrahydro-furan-3-yloxy)-pyridine-2-carboxylic acid 
• 1191263-86-1 4-((R)-4-(diethoxy-phosphoryl)-2-([4-((S)-3-methoxy-pyrrolidin-1-yl)-6-phenyl-pyridine-2-carbonyl]-amino)-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 1191263-36-1 4-((R)-2-([4-((S)-3-methoxy-pyrrolidin-1-yl)-6-phenyl-pyridine-2-carbonyl]-amino)-4-phosphono-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 1152096-35-9 ethyl 4-hydroxy-6-phenylpyridine-2-carboxylate 
• 1241726-43-1 4-hydroxy-6-phenylpyridine-2-carbohydrazide 
• 905589-13-1 4-(benzyloxy)-6-phenylpyridine-2-carboxylic acid benzyl ester 
• 1191264-31-9 4-[(R)-3-(diethoxy-phosphoryl)-2-({6-phenyl-4-[(tetrahydro-furan-3-yl)oxy]-pyridine-2-carbonyl}-amino)-propionyl]-piperazine-1-carboxylic acid butyl ester 
• 1191263-81-6 4-[(R)-2-({6-phenyl-4-[(tetrahydrofuran-3-yl)oxy]-pyridine-2-carbonyl}-amino)-3-phosphono-propionyl]-piperazine-1-carboxylic acid butyl ester 
• 1214284-56-6 hexyl 4-((2S)-5-tert-butoxy-2-([(4-hydroxy-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl)piperazine-1-carboxylate 
• 1214284-54-4 butyl 4-((2S)-5-tert-butoxy-2-([(4-hydroxy-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl)piperazine-1-carboxylate 
• 1214284-55-5 pentyl 4-((2S)-5-tert-butoxy-2-([(4-hydroxy-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED 2-PHENYL-PYRIDINE DERIVATIVES

The present invention relates to compounds of formula I wherein R1, R2, R4, R5, Ra, Rb, n, W and Z are as defined in the application, their preparation and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

New derivatives of 6-phenylcomanic acid

Ethyl 6-phenylcomanic acid with hydrazine hydrate and hydroxylamine gives 4-oxo-6-phenyl-4H/-pyran-2-carbohydrazide and 4-oxo-6-phenyl-4H-pyran-2- carbohydroxamic acid, whereas 6-phenylcomanic acid with ammonia in aqueous DMSO gives 4-hydroxy-6-phenylpico

SUBSTITUTED 2-PHENYL-PYRIDINE DERIVATIVES

The present invention relates to compounds of formula (I) wherein R1, R2, R4, R5, Ra, Rb, n, W and Z are as defined in the application, their preparation and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

Antiallergic agents. 2. N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides

A new series of N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides was prepared to determine the effects of substituents on the benzene and pyridine rings on antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) assay after oral administr