7500-03-0

Basic information

• Product Name: 2-methyl-6-phenylpyridin-4(1H)-one
• CAS NO: 7500-03-0
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.2218
• Mol File: 7500-03-0.mol

Chemical Properties

• Boiling Point: 339.9°C at 760 mmHg
• Flash Point: 146.2°C
• Density: 1.117g/cm³
• Vapor Pressure: 8.94E-05mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2-methyl-6-phenylpyridin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-6-phenylpyridin-4(1H)-one(7500-03-0)
• EPA Substance Registry System: 2-methyl-6-phenylpyridin-4(1H)-one(7500-03-0)

Safety Data

• Hazardous Substances Data: 7500-03-0(Hazardous Substances Data)

Upstream product

• 27349-51-5 (3-methyl-5-isoxazolyl)methyl phenyl ketone 
• 143889-62-7 1-amino-5-(N-phenylamino)-1-phenylhexa-1,4-dien-3-one 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 93-58-3 benzoic acid methyl ester 
• 26567-78-2 (Z)-4-(phenylamino)-3-penten-2-one 
• 100-47-0 benzonitrile 
• 123-54-6 acetylacetone 

Downstream Products

• 412923-41-2 4-chloro-2-methyl-6-phenyl-pyridine 
• 1019927-24-2 4-cyclopentyloxy-2-methyl-6-phenyl-pyridine 
• 1019929-28-2 4-((S)-3-methoxy-pyrrolidin-1-yl)-6-phenyl-pyridine-2-carboxylic acid 
• 78296-37-4 4-hydroxy-6-phenylpyridine-2-carboxylic acid 
• 85814-98-8 4-methoxy-6-phenylpyridine-2-carboxylic acid 
• 1191264-25-1 4-(2-methoxy-ethoxy)-6-phenyl-pyridine-2-carboxylic acid 
• 1191264-30-8 6-phenyl-4-(tetrahydro-furan-3-yloxy)-pyridine-2-carboxylic acid 
• 1191263-83-8 4-chloro-6-phenyl-pyridine-1-carboxylic acid ethyl ester 
• 1191263-86-1 4-((R)-4-(diethoxy-phosphoryl)-2-([4-((S)-3-methoxy-pyrrolidin-1-yl)-6-phenyl-pyridine-2-carbonyl]-amino)-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 1191263-36-1 4-((R)-2-([4-((S)-3-methoxy-pyrrolidin-1-yl)-6-phenyl-pyridine-2-carbonyl]-amino)-4-phosphono-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 1191263-81-6 4-[(R)-2-({6-phenyl-4-[(tetrahydrofuran-3-yl)oxy]-pyridine-2-carbonyl}-amino)-3-phosphono-propionyl]-piperazine-1-carboxylic acid butyl ester 
• 1191264-31-9 4-[(R)-3-(diethoxy-phosphoryl)-2-({6-phenyl-4-[(tetrahydro-furan-3-yl)oxy]-pyridine-2-carbonyl}-amino)-propionyl]-piperazine-1-carboxylic acid butyl ester 

Relevant articles and documents

SUBSTITUTED 2-PHENYL-PYRIDINE DERIVATIVES

The present invention relates to compounds of formula I wherein R1, R2, R4, R5, Ra, Rb, n, W and Z are as defined in the application, their preparation and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

SUBSTITUTED 2-PHENYL-PYRIDINE DERIVATIVES

The present invention relates to compounds of formula (I) wherein R1, R2, R4, R5, Ra, Rb, n, W and Z are as defined in the application, their preparation and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

2-AMINOCARBONYL-PYRIDINE DERIVATIVES

The present invention relates to 2-aminocarbonyl-pyridine derivatives and their use as P2Yi2 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

Mo(CO)6-INDUCED N-O BOND CLEAVAGE OF ISOXAZOLES. A CONVENIENT ROUTE TO PYRIDIN-4(1H)-ONES

The Mo(CO)6-induced reaction of 3-methyl-5-(2-oxoalkyl)isoxazoles, which are derived through proton-abstraction of 3,5-dimethylisoxazole followed by treatment with esters, gave pyridin-4(1H)-ones in good to modest yields in a single step.

Reaction of Dianions of Acyclic β-Enamino Ketones with Electrophiles. 3. Nitriles: Synthesis of Pyridine and Pyrimidine Derivatives

A new method for the construction of pyridine and pyrimidine derivatives is described, based on the electrophilic attack of nitriles to dianions of β-(monoalkylamino)-α,β-unsaturated ketones and the subsequent cyclization of the addition product.The react

Polycarbonylmethyl Derivatives: Reactions of 2-(3-Methyl-5-isoxazolyl)-1-phenylethanone

Starting with the compound 11, the isoxazole derivatives 22a and 27a are synthesized.These compounds are transformed to the substituted isoxazoles 23, 25 and 28.Catalytic hydrogenation of the isoxazol derivatives 11, 15 and 23 gives the 1,3,5-tricarbonyl