783241-21-4

Basic information

• Product Name: 3-Chloro-4-fluoro-L-phenylalanine
• Synonyms: (2S)-2-AMINO-3-(3-CHLORO-4-FLUOROPHENYL)PROPANOIC ACID;3-Chloro-4-fluoro-L-phenylalanine
• CAS NO: 783241-21-4
• Molecular Formula: C9H9ClFNO2
• Molecular Weight: 217.6246632
• Mol File: 783241-21-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Chloro-4-fluoro-L-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-fluoro-L-phenylalanine(783241-21-4)
• EPA Substance Registry System: 3-Chloro-4-fluoro-L-phenylalanine(783241-21-4)

Safety Data

• Hazardous Substances Data: 783241-21-4(Hazardous Substances Data)

Upstream product

• 34328-61-5 3-Chloro-4-fluorobenzaldehyde 
• 155814-22-5 (E)-3-(3-chloro-4-fluorophenyl)acrylic acid 
• 452-84-6 3-amino-4-fluorotoluene 
• 192702-01-5 3-chloro-4-fluorobenzyl bromide 
• 1513-25-3 2-chloro-1-fluoro-4-methylbenzene 
• 14937-92-9 α-(3-Chlor-4-fluor-benzyl)-α-acetamino-malonsaeure-diethylester 

Relevant articles and documents

Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes

A chemo-enzymatic telescopic approach was designed for the synthesis of L-arylalanines in high yield and optical purity, starting from commercially available and inexpensive substituted benzaldehydes. The method exploits a chemical Knoevenagel–Doebner condensation (optimised to give complete conversions in a short reaction time, employing microwave irradiation) and a biocatalytic phenylalanine ammonia lyase mediated hydroamination (for the stereoselective addition of ammonia). The two reactions can be run sequentially in one pot, bringing together the advantages of chemical and biological catalysis. The preparative applicability was demonstrated with the synthesis of five L-dihalophenylalanines (71–84% yield, 98–99% ee) of relevance as molecular probes, for medicinal chemistry and for the synthesis of pharmaceutical ingredients.