784183-51-3

Upstream product

• 63069-48-7 p-chloro-o-iodoaniline 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 23746-76-1 5-chloro-2-phenylindole 
• 618889-14-8 N-(4-Chloro-2-cyanophenyl)-2,2,2-trifluoroacetamide 
• 63069-48-7 p-chloro-o-iodoaniline 
• 1677-50-5 2,4,6-trichloroquinoline 
• 20028-68-6 2,4,6-trichloroquinazoline 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 412947-46-7 4-chloro-2-ethynylaniline 
• 180624-15-1 4-chloro-2-trimethylsilanylethynyl-phenylamine 
• 1419006-62-4 4-{[(4-chloro-2-iodo-phenyl)-(2,2,2-trifluoro-acetyl)-amino]-methyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1332828-77-9 bis-(O-toluoyl)-1β-{[2-(N-trifluoroacyl)-5-chlorophenyl]ethynyl}deoxyribose 
• 1332828-73-5 bis-(O-toluoyl)-1α-{[2-(N-trifluoroacyl)-5-chlorophenyl]ethynyl}deoxyribose 
• 1332828-81-5 bis-(O-toluoyl)-1α-(1H-5-chloroindol-2-yl)deoxyribose 
• 1332828-85-9 bis-(O-toluoyl)-1β-(1H-5-chloroindol-2-yl)deoxyribose 
• 1176667-12-1 C₁₆H₁₀ClF₃N₂O 

Relevant academic research and scientific papers

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

Novel indolotacrine analogues were designed, synthesized, and evaluated as potential drugs for the treatment of Alzheimer's disease. By using a multitarget-directed ligand approach, compounds were designed to act simultaneously as cholinesterase (ChE) and

Regio- and chemoselective n-1 acylation of indoles: Pd-catalyzed domino cyclization to afford 1,2-fused tricyclic indole scaffolds

A concise method for the synthesis of 1,2-fused tricyclic indole scaffolds by domino cyclization involving a Pd-catalyzed Sonogashira coupling, indole cyclization, regio- and chemoselective N-1 acylation, and 1,4-Michael addition is reported. This method

Self-induced stereoselective in situ trifluoromethylation: Preparation of spiro[indoline-3,3′-quinoline] via palladium-catalyzed cascade reaction

An efficient method to prepare 1′H-spiro[indoline-3,3′- quinoline]-2′,4′-diones and their trifluoromethylated products was developed via a palladium-catalyzed Sonogashira coupling/Wacker-type oxypalladation/cyclization cascade reaction. The amount of wate

Acetonitrile-mediated synthesis of 2,4-dichloroquinoline from 2-ethynylaniline and 2,4-dichloroquinazoline from anthranilonitrile

2,4-Dichloroquinolines and 2,4-dichloroquinazolines were synthesized from 2-ethynylanilines and anthranilonitriles, respectively, using diphosgene in acetonitrile and heating at 130 °C or 150 °C for 12 hours. This reaction was applied to the synthesis of 4,6-dichloropyrazolo[3,4-d]pyrimidine (dichloro-9H-isopurine). The postulated mechanism is also described. Georg Thieme Verlag Stuttgart.