78427-50-6Relevant academic research and scientific papers
Titanium-mediated carboxylation of alkynes with carbon dioxide
Six, Yvan
, p. 1157 - 1171 (2003)
The regioselective carboxylation of nonactivated internal alkynes can be performed with carbon dioxide under atmospheric pressure using a simple procedure based on the chemistry of Sato-type diisopropyloxytitanacyclopropenes. Various polysubstituted vinylcarboxylic acids and butenolides can be prepared in this way. In addition, this paper describes an experimental protocol for the preparation of solutions of (η2-cyclopentene)diisopropyloxytitanium. This complex also reacts with carbon dioxide, and mediates pinacol coupling of acetophenone. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
A Simple and Efficient Route to 2-Alkyl-2-alkenoic Acids and 2-Phenyl-2-Alkenoic Acids by the Horner Synthesis. Application to the Steroselective Synthesis of the Pheromone Manicone
Coutrot, Philippe,Ghribi, Abdellaziz
, p. 790 - 792 (2007/10/02)
A general synthesis of α-branched α,β-unsaturated carboxylic acids is described.A Horner reaction of 2-diethoxyphosphorylalkanoic acid dianions (lithium α-lithiocarboxylates) with carbonyl compounds is used.The reaction is applied to the stereoselective synthesis of Manicone.
Structural Effects of the Acidity of E-α-Phenyl-β-arylacrilic Acids
Maccarone, Emanuele,Mamo, Antonino,Perrini, Giancarlo,Torre, Michele
, p. 395 - 398 (2007/10/02)
The dissociation equilibrium constants of some E-α-phenyl-β-arylacrilic acids (Ar=2-pyridyl, 3-pyridyl, 4-pyridyl, 1-naphthyl, 2-naphthyl, anthracen-9-yl) have been measured in 80percent aqeous 2-methoxyethanol at 25 deg C., The pKa values of these acids, together with those of p-substituted phenyl, 2-furyl, 2-thienyl and selenophen-2-yl derivitives, have been rationalized by an equation involving separate contributions of polar, conjugative and steric effects of heterocycles.The pKa values of some E-α-phenyl-β-alkylacrilic acids (alk=methyl; ethyl; n-propyl; i-propyl; n-butyl; i-butyl) are also reported.
