78564-23-5

Upstream product

• 126985-27-1 3-Cyano-6-hydroxy-6-methyl-4-phenyl-5-(1-pyridinio)-4,5-trans-1,4,5,6-tetrahydro-2-pyridinethiolate 
• 7357-70-2 Cyanothioacetamide 
• 100-52-7 benzaldehyde 
• 67-64-1 acetone 
• 109-77-3 malononitrile 
• 94639-04-0 6-Amino-2,2-dimethyl-4-phenyl-4H-[1,3]dithiine-5-carbonitrile 
• 2700-22-3 Benzylidenemalononitrile 
• 1687-47-4 propane-2,2-dithiol 
• 102434-73-1 2,6-diamino-4-phenyl-3,5-dicyano-4H-thiopyran 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 93-91-4 1-phenylbutan-1,3-dione 
• 72740-50-2 4-amino-6-phenyl-5-cyano-2-cyclohexanespiro-1,3-dithia-4-cyclohexene 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 68029-52-7 (E)-2-cyano-3-phenylprop-2-enethioamide 

Downstream Products

• 94638-98-9 3-Amino-6-methyl-4-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid amide 
• 78564-34-8 2-Ethylsulfanyl-6-methyl-4-phenyl-nicotinonitrile 
• 94638-93-4 3-amino-6-methyl-2-phenyl-2-cyanothieno<2,3-b>pyridine 
• 94638-94-5 3-Amino-6-methyl-4-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid methyl ester 
• 94638-95-6 3-Amino-6-methyl-4-phenyl-thieno<2,3-b>pyridin-2-carbonsaeureethylester 
• 96517-70-3 (3-Cyano-6-methyl-4-phenyl-pyridin-2-ylsulfanyl)-acetic acid ethyl ester 
• 94638-96-7 (3-amino-6-methyl-4-phenyl-thieno[2,3-b]pyridin-2-yl)-phenyl-methanone 
• 94638-97-8 (3-Amino-6-methyl-4-phenyl-thieno[2,3-b]pyridin-2-yl)-(4-bromo-phenyl)-methanone 
• 96539-80-9 6-Methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-4-phenyl-nicotinonitrile 
• 128918-17-2 3-Amino-6-methyl-4-phenyl-thieno<2,3-b>pyridin-2-carbonsaeureamid 
• 152068-90-1 Ni((C₆H₅)(CH₃)C₅HNS(CN))2 
• 78564-26-8 C₂₆H₁₈N₄S₂ 
• 82447-80-1 3-Bromo-6-methyl-4-phenyl-isothiazolo[5,4-b]pyridine 
• 82447-77-6 6-Methyl-4-phenyl-isothiazolo[5,4-b]pyridin-3-one 

Relevant academic research and scientific papers

Synthesis of 4,6-Disubstituted 2-Thioxo-1,2-dihydropyridine-3-carbonitriles by the Reaction of Acetylenic Ketones with Cyanothioacetamide

The reaction of acetylenic ketones with cyanothioacetamide in the presence of morpholine yields 4,6-disubstituted 2-thioxo-1,2-dihydropyridine-3-carbonitriles. Structure of the obtained compounds was proved using 2D NMR spectroscopy, as well as transformations into 3-aminothieno[2,3-b]pyridine-2-carboxamide derivatives.

SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, SUBSTITUTED THIENO[2,3-D:4,5-D']DIPYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, SUBSTITUTED PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND SUBSTITUTED FURO[2,3-D:4,5-D']DIPYRIMIDINE-2,4(1 H,3H)-DIONES AN

The invention relates to novel pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=C-H, Y=S), thieno[2,3-d:4,5-d']dipyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=N, Y=S), in addition to pyrido[3',2':4,5]furo[3,2-d]pyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=C-H, Y=0) and furo[2,3-d:4,5-d']dipyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=N, Y=O) of general formulae 1a and 1b. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or tautomers thereof and physiologically compatible salts which can be produced therefrom and/or solvates thereof, in addition to the pharmaceutical use of said compounds, tautomers thereof, salts or solvates, as inhibitors of TNFa-release.

CYCLIZATION OF NITRILES. XXXIV. TRANSFORMATION OF 4-ARYL-2,6-DIAMINO-3,5-DICYANO-4H-THIOPYRANS INTO SUBSTITUTED 4-ARYL-3-CYANO-2(1H)-PYRIDINETHIONES AND 2-AMINO-4-ARYL-7,7-DIMETHYL-5-OXO-3-CYANO-5,6,7,8-TETRAHYDRO-4H-BENZOPYRANS

The reaction of 2,6-diamino-3,5-dicyano-4H-thiopyrans with monocarbonyl and acyclic 1,3-dicarbonyl compounds leads to the elimination of malononitrile and the formation of substituted 4-aryl-3-cyano-2(1H)-pyridinethiones.The reaction with 1,3-cycloalkanediones leads to the elimination of cyanothioacetamide and the formation of 2-amino-4-aryl-3-cyano-4H-benzopyrans.

CYCLIZATION OF NITRILES. XIII. 2,2-DIALKYL-4-AMINO-6-ARYL-5-CYANO-1,3-DITHIA-4-CYCLOHEXENES IN THE SYNTHESIS OF 4-ARYL-3-CYANOPYRIDINE-2(1H)-THIONES AND THEIR HETEROCYCLIC TRANSFORMATION PRODUCTS

2,2-Dialkyl-4-amino-6-aryl-5-cyano-1,3-dithia-4-cyclohexenes were obtained in the reaction of 2,2-propane- and 2,2-butanedithiols with arylidenemalononitrile.As a result of recyclization they formed substituted 4-aryl-3-cyanopyridine-2(1H)-thiones.The synthesized compounds were used in the synthesis of various 3-aminothienopyridines and some of their derivatives.