78564-30-4

Upstream product

• 58327-74-5 4,6-diphenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 96-32-2 bromoacetic acid methyl ester 
• 82127-26-2 2-bromo-4,6-diphenylpyridine-3-carbonitrile 
• 62940-90-3 2-(3-oxo-1,3-diphenylpropyl)malononitrile 
• 94-41-7 benzalacetophenone 
• 120-46-7 1,3-diphenylpropanedione 
• 100-52-7 benzaldehyde 
• 7196-01-2 4-(1-phenylvinyl)morpholine 

Relevant academic research and scientific papers

Synthesis of 2-thioxo-4,6-diphenyl-1,2-dihydronicotinonitrile via condensation of benzaldehyde with cyanothioacetamide and p-(1-styryl)morpholine

2-Thioxo-4,6-diphenyl-1,2-dihydronicotinonitrile has been prepared via condensation of benzaldehyde with cyanothioacetamide and N-(1-styryl)morpholine; alkylation of the product with alkyl halides has afforded substituted 2-alkylsulfanyl-4,6-diphenylnicotinonitriles and 3-amino-2-acyl-4,6-diphenylthieno[2,3-b]pyridines.

CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES

2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.

SYNTHESIS AND SOME REACTIONS OF 3-CYANOPYRIDINE-2-THIONES

New method for the synthesis of 3-cyanopyridine-2-thiones by the reaction of δ-keto nitroles with sulfur and by condensation of chalcones or benzylideneacetone with cyanothioacetamide are given.The compounds obtained were used in various reactions for the preparation of alkylated products, disulfides, and condensed heterocycles, viz., thienopyridines and pyridothienopyrimidines.