78583-87-6

Usage

General Description

3-(4-Bromophenyl)-3-chloroacrylonitrile is a chemical compound that consists of a 3-(4-bromophenyl) group attached to a 3-chloroacrylonitrile group. It is primarily used in the production of pharmaceuticals and agrochemicals. 3-(4-BROMOPHENYL)-3-CHLOROACRYLONITRILE is highly reactive and can act as a versatile building block for the synthesis of various organic molecules. It is also used as an intermediate in the manufacturing of dyes, pigments, and other fine chemicals. However, it is important to handle 3-(4-BROMOPHENYL)-3-CHLOROACRYLONITRILE with caution, as it may pose health and safety risks if not properly managed.

Upstream product

• 99-90-1 para-bromoacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 14063-78-6 3-(4-bromophenyl)-3-chloroprop-2-enal 
• 52117-14-3 3-(4-Bromphenyl)-3-chlor-1-dimethylimmoniumpropen-⁽²⁾ 
• 72806-46-3 4-bromo-β-chloro-cinnamaldehyde-oxime 

Downstream Products

• 78583-82-1 3-(4-bromophenyl)-1H-pyrazol-5-amine 
• 91076-95-8 methyl 3-amino-5-(4’-bromophenyl)thiophene-2-carboxylate 
• 91076-96-9 3-Amino-5-(4-bromo-phenyl)-thiophene-2-carboxylic acid ethyl ester 
• 126417-84-3 5-(4-bromophenyl)-2-methyl-pyrazol-3-amine 
• 126417-83-2 5-(4-Bromo-phenyl)-1-methyl-1H-pyrazol-3-ylamine 
• 649757-40-4 6-(4’-bromophenyl)-2,4-dihydro-1H-thieno[3,2-d][1,3]oxazine-2,4-dione 
• 6525-98-0 3-amino-5-(4-bromophenyl)isoxazole 
• 126418-05-1 N-[5-(4-Bromo-phenyl)-2-methyl-2H-pyrazol-3-yl]-4-methyl-benzenesulfonamide 
• 126417-97-8 N-[5-(4-Bromo-phenyl)-1-methyl-1H-pyrazol-3-yl]-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

One-pot synthesis of 2-substituted thieno[3,2-b]indoles from 3-aminothiophene-2-carboxylates through in situ generated 3-aminothiophenes

A convenient protocol for one-pot synthesis of thieno[3,2-b]indoles, bearing aromatic, thien-2-yl or styryl fragments at C-2 position, from easily accessible 5-substituted 3-aminothiophene-2-carboxylates using the Fischer indolization reaction, was develo

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

The clinical evidence for the success of tyrosine kinase inhibitors in combination with microtubule-targeting agents prompted us to design and develop single agents that possess both epidermal growth factor receptor (EGFR) kinase and tubulin polymerization inhibitory properties. A series of 6-aryl/heteroaryl-4-(3′,4′,5′-trimethoxyanilino)thieno[3,2-d]pyrimidine derivatives were discovered as novel dual tubulin polymerization and EGFR kinase inhibitors. The 4-(3′,4′,5′-trimethoxyanilino)-6-(p-tolyl)thieno[3,2-d]pyrimidine derivative 6g was the most potent compound of the series as an antiproliferative agent, with half-maximal inhibitory concentration (IC50) values in the single- or double-digit nanomolar range. Compound 6g bound to tubulin in the colchicine site and inhibited tubulin assembly with an IC50 value of 0.71 μM, and 6g inhibited EGFR activity with an IC50 value of 30 nM. Our data suggested that the excellent in vitro and in vivo profile of 6g may be derived from its dual inhibition of tubulin polymerization and EGFR kinase.

Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa

Pseudomonas aeruginosa employs a quorum sensing (QS) communication system that makes use of small diffusible molecules. Among other effects, the QS system coordinates the formation of biofilm which decisively contributes to difficulties in the therapy of

Novel small molecule inhibitors targeting the "switch region" of bacterial RNAP: Structure-based optimization of a virtual screening hit

Rising resistance against current antibiotics necessitates the development of antibacterial agents with alternative targets. The "switch region" of RNA polymerase (RNAP), addressed by the myxopyronins, could be such a novel target site. Based on a hit can

Combining in silico and biophysical methods for the development of pseudomonas aeruginosa quorum sensing inhibitors: An alternative approach for structure-based drug design

The present work deals with the optimization of an inhibitor of PqsD, an enzyme essential for Pseudomonas aeruginosa quorum sensing apparatus. Molecular docking studies, supported by biophysical methods (surface plasmon resonance, isothermal titration cal

A Simple Synthesis of β-Chlorocinnamonitriles by a Modified Vilsmeier-Haack-Arnold-Reaction

A simple one-pot synthesis of β-chloro-cinnamonitriles 2 can be achieved by treating acetyl arenes 1 first with formamide chlorides and subsequently with hydroxyl amine hydrochloride.The formamide chlorides used are conveniently prepared from an excess of