6525-98-0

Usage

General Description

5-(4-Bromophenyl)isoxazol-3-amine is a chemical compound with the molecular formula C9H7BrN2O. It is a derivative of isoxazole and contains a bromine atom attached to a phenyl group. 5-(4-BROMOPHENYL)ISOXAZOL-3-AMINE is commonly used in the field of chemical research and is often utilized as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its structure and properties make it a valuable tool for medicinal chemistry, where it can be used to develop new drugs and study the biological activity of certain molecules. Additionally, the bromine atom in its structure makes it useful for radiolabeling and positron emission tomography studies in the field of nuclear medicine. Overall, 5-(4-bromophenyl)isoxazol-3-amine is a versatile and important chemical compound with a wide range of applications in various scientific and industrial fields.

Upstream product

• 1824-00-6 3-bromo-3-(4-bromo-phenyl)-acrylonitrile 
• 845866-13-9 methyl 2-(acetoxy-(4-bromophenyl)methyl)acrylate 
• 41501-66-0 1-(4-bromophenyl)-3,3-dichloro-2-propen-1-one 
• 99-90-1 para-bromoacetophenone 
• 78583-87-6 (E)-3-(4-Bromo-phenyl)-3-chloro-acrylonitrile 
• 14063-78-6 3-(4-bromophenyl)-3-chloroprop-2-enal 

Relevant academic research and scientific papers

Efficient Transformation of Alkyl 3-nitro-5-(aryl/alkyl)isoxazole-4-carboxylates into 3-amino- and 3-hydrazinyl-5-aryl/alkyl-isoxazole-4-carboxylates in Aqueous Solution

An efficient protocol for transforming alkyl 3-nitro-5-(aryl/alkyl)isoxazole-4-carboxylates into 3-amino- and 3-hydrazinyl-5-aryl/alkyl-isoxazole-4-carboxylates is described. The reaction that is carried out in aqueous acetonitrile solution generally afford the products without any chromatographic purification. Investigations with the substrate scope reveal that this protocol is compatible only when the ester group is present at the C-4 position of the isoxazole ring. (Figure presented.).

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

Functionalized β,β-dichloroenones and β,β-dibromoenones as versatile building blocks: Synthesis and transformations

An efficient one-step synthesis of functionalized β,β-dichloroenones and β,β-dibromoenones was achieved via the Fe-catalyzed radical induced reaction between silyl enol ethers and carbon tetrachloride, bromotrichloromethane or carbon tetrabromide in moderate to good yields. This reaction proceeds through addition of the trichloromethyl or tribromomethyl radical group to the C[dbnd]C bond of the silyl enol ethers and subsequent base-induced elimination under mild conditions.

The study of reactions of α-chlorocinnamonitriles with hydroxylamine

The E-isomers of α-chlorocinnamonitriles react with hydroxylamine to give a mixture of isomeric aminoisoxazoles, while the Z-isomers yield 3-aryl-2-chloroacrylamide oximes.