6525-98-0Relevant articles and documents
Efficient Transformation of Alkyl 3-nitro-5-(aryl/alkyl)isoxazole-4-carboxylates into 3-amino- and 3-hydrazinyl-5-aryl/alkyl-isoxazole-4-carboxylates in Aqueous Solution
Mukhopadhyay, Sushobhan,Barak, Dinesh S.,Avasthi, Ilesha,Batra, Sanjay
, p. 4050 - 4056 (2017)
An efficient protocol for transforming alkyl 3-nitro-5-(aryl/alkyl)isoxazole-4-carboxylates into 3-amino- and 3-hydrazinyl-5-aryl/alkyl-isoxazole-4-carboxylates is described. The reaction that is carried out in aqueous acetonitrile solution generally afford the products without any chromatographic purification. Investigations with the substrate scope reveal that this protocol is compatible only when the ester group is present at the C-4 position of the isoxazole ring. (Figure presented.).
Functionalized β,β-dichloroenones and β,β-dibromoenones as versatile building blocks: Synthesis and transformations
Li, Dengke
, (2021/11/30)
An efficient one-step synthesis of functionalized β,β-dichloroenones and β,β-dibromoenones was achieved via the Fe-catalyzed radical induced reaction between silyl enol ethers and carbon tetrachloride, bromotrichloromethane or carbon tetrabromide in moderate to good yields. This reaction proceeds through addition of the trichloromethyl or tribromomethyl radical group to the C[dbnd]C bond of the silyl enol ethers and subsequent base-induced elimination under mild conditions.
