787-46-2

Usage

Uses

Used in Pharmaceutical Industry:
1(2H)-Isoquinolinone, 3-(phenylmethyl)is used as a building block for the development of various pharmaceuticals due to its versatile intermediate structure in organic synthesis.
Used in Medicinal Chemistry:
1(2H)-Isoquinolinone, 3-(phenylmethyl)is used as a precursor in the synthesis of other biologically active compounds, contributing to the development of new drugs.
Used in Treatment of Neurological and Psychiatric Disorders:
1(2H)-Isoquinolinone, 3-(phenylmethyl)is used as a potential therapeutic agent for the treatment of various neurological and psychiatric disorders, such as addiction, depression, and schizophrenia, due to its studied effects on these conditions.
Used in Analgesic and Anti-inflammatory Applications:
1(2H)-Isoquinolinone, 3-(phenylmethyl)is used for its analgesic and anti-inflammatory properties, making it a valuable target for the development of new pain relief and inflammation management drugs.

Upstream product

• 873404-52-5 3-benzyl-3,4-dihydroisoquinolin-1(2H)-one 
• 10147-11-2 propargyl benzene 
• 2327-99-3 1-phenylpropadiene 
• 3930-83-4 o-iodobenzamide 
• 1829-28-3 ethyl 2-iodobenzoate 
• 253435-17-5 2-(3-phenyl-1-propynyl)-1-iodobenzene 
• 615-42-9 1,2-Diiodobenzene 
• 253177-44-5 1-benzyl-2-phenyl-ethyl isocyanate 
• 4275-43-8 1-benzyl-2-phenylethylamine 

Downstream Products

• 872788-04-0 3-benzyl-1-chloro-isoquinoline 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of tetrasubstituted pyridines as potent 5-HT2C receptor agonists

A series of pyrido[3,4-d]azepines that are potent and selective 5-HT2C receptor agonists is disclosed. Compound 7 (PF-04781340) is identified as a suitable lead owing to good 5-HT2C potency, selectivity over 5-HT2B agonism, and in vitro ADME properties commensurate with an orally available and CNS penetrant profile. The synthesis of a novel bicyclic tetrasubstituted pyridine core template is outlined, including rationale to account for the unexpected formation of aminopyridine 13 resulting from an ammonia cascade cyclization.

Cobaltaelectro-catalyzed oxidative allene annulation by electro-removable hydrazides

An efficient C-H/N-H functionalization with allenes was enabled via versatile electro-oxidative cobalt catalysis. Thus, electrochemical C-H activations were accomplished with high levels of chemoselectivity and regioselectivity in an operationally simple

Palladium-Catalyzed Regioselective C-H Functionalization/Annulation Reaction of Amides and Allylbenzenes for the Synthesis of Isoquinolinones and Pyridinones

A regioselective C-H functionalization/annulation reaction of N-sulfonyl amides and allylbenzenes through a palladium-catalyzed C(sp2)-H allylation/aminopalladation/β-H elimination/isomerization sequence has been reported. Various aryl and alkenyl carboxamides are found to be efficient substrates to construct isoquinolinones and pyridinones in up to 96% yield. Using ambient air as the terminal oxidant is another advantage regarding environmental friendliness and operational simplicity.

Polysubstituted isoquinoline-1(2H)-one derivative and preparation method thereof

The invention discloses a polysubstituted isoquinoline-1(2H)-one derivative and a preparation method thereof, and relates to the fields of organic synthesis and electrochemistry. The polysubstituted isoquinoline-1(2H)-one derivative has a structure repres

Isoquinolinone derivatives

Derivatives of isoquinolinone and dihydrolisoquinolinone, and related compounds, and their use as pharmaceuticals in the treatment of a disease by inhibition of the enzyme poly(ADP-ribose)polymerase (“PARP”) are disclosed.

A direct anionic cyclization of 2-alkynylbenzonitrile to 3- substituted-1(2H)-isoquinolones and 3-benzylideneisoindol-2ones initiated by methoxide addition

Treatment of 2-(2-alkylethynyl)benzonitrile with sodium methoxide in refluxing methanol for 12 h gave 3-alkyl-1(2H)- isoquinolone in modest yield. Under the same reaction conditions, methanolysis of 2-(2-arylethynyl)benzonitrile lead to the formation of 3