78811-33-3

Basic information

• Product Name: 3-Cyclohexyl-2-phenylpropionsaeure-ethylester
• CAS NO: 78811-33-3
• Molecular Weight: 260.376
• Mol File: 78811-33-3.mol

Chemical Properties

• CAS DataBase Reference: 3-Cyclohexyl-2-phenylpropionsaeure-ethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyclohexyl-2-phenylpropionsaeure-ethylester(78811-33-3)
• EPA Substance Registry System: 3-Cyclohexyl-2-phenylpropionsaeure-ethylester(78811-33-3)

Safety Data

• Hazardous Substances Data: 78811-33-3(Hazardous Substances Data)

Upstream product

• 108-85-0 1-bromocyclohexane 
• 15895-95-1 ethyl 2-phenylacrylate 
• 25944-64-3 diethyl (1-phenylethenyl)phosphonate 
• 98-89-5 Cyclohexanecarboxylic acid 
• 10341-90-9 Cyclohexylquecksilberacetat 
• 22286-82-4 2-phenyl-acrylic acid ethyl ester 
• 24371-94-6 cyclohexylmercury chloride 

Relevant articles and documents

Visible-Light-Promoted Decarboxylative Giese Reactions of α-Aryl Ethenylphosphonates and the Application in the Synthesis of Fosmidomycin Analogue

An approach for the synthesis of α-aryl alkylphosphonates based on visible-light photocatalytic Giese reaction of α-aryl vinylphosphonates with aliphatic carboxylic acids has been successfully developed. This protocol tolerates a wide range of functional

Alkyl-GeMe3: Neutral Metalloid Radical Precursors upon Visible-Light Photocatalysis

Single-electron transfer (SET) oxidation of ionic hypervalent complexes, in particular alkyltrifluoroborates (Alkyl-BF3?) and alkylbis(catecholato)silicates (Alkyl-Si(cat)2?), have contributed substantially to alkyl radical generation compared to alkali or alkaline earth organometallics because of their excellent activity–stability balance. Herein, another proposal is reported by using neutral metalloid compounds, Alkyl-GeMe3, as radical precursors. Alkyl-GeMe3 shows comparable activity to that of Alkyl-BF3? and Alkyl-Si(cat)2? in radical addition reactions. Moreover, Alkyl-GeMe3 is the first successful group 14 tetraalkyl nucleophile in nickel-catalyzed cross-coupling. Meanwhile, the neutral nature of these organogermanes offset the limitation of ionic precursors in purification and derivatization. A preliminary mechanism study suggests that an alkyl radical is generated from a tetraalkylgermane radical cation with the assistance of a nucleophile, which may also result in the development of more non-ionic alkyl radical precursors with a metalloid center.

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Polar Substituent Effects in Additions of Alkyl Radicals to Alkenes

Reduction of cyclohexylmercuric salts (7) with NaBH4 yields cyclohexyl radicals (8).Their rel. rates of addition to substituted styrenes 4, acrylic esters 5 and acrylonitriles 6 have been measured.Comparison with Hammett ?-values shows, that substituents at the non attacked vinylic carbon atom show polar effects mainly (Table 1).The effect of a substituent variation increases with increase of the reactivity of the alkenes (Table 2).Mesomeric and steric effects play only a minor role.