78815-30-2

Upstream product

• 65100-24-5 dibenzyl 2-bromomalonate 
• 34103-69-0 (1E,5R)-3-Phenylmethyl-4-thia-2,6-diazabicyclo[3.2.0]hept-2-en-7-one 
• 15014-25-2 malonic acid dibenzyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 78815-32-4 2-((2R,3R)-2-Mercapto-4-oxo-3-phenylacetylamino-azetidin-1-yl)-malonic acid dibenzyl ester 
• 87044-36-8 (5R,6R)-3-[(Z)-Methylimino]-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester 
• 87035-96-9 (5R,6R)-3-Methylamino-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

A GENERAL ROUTE TOWARD 2-OXO-, 2-THIOXO- AND 2-IMINOPENAMS AND THEIR CONVERSION INTO 2-ALKOXY-, 2-ALKYLTHIO- AND 2-AMINOPENEMS

A convenient methodology is described which allows the preparation of 2-oxo-, 2-thioxo- and 2-iminopenams from a single precursor readily prepared from penicillin G.These penams have been converted into the corresponding 2-heterosubstituted penems.