A GENERAL ROUTE TOWARD 2-OXO-, 2-THIOXO- AND 2-IMINOPENAMS AND THEIR CONVERSION INTO 2-ALKOXY-, 2-ALKYLTHIO- AND 2-AMINOPENEMS

Article abstract of DOI:10.1016/S0040-4039(00)81982-6

A convenient methodology is described which allows the preparation of 2-oxo-, 2-thioxo- and 2-iminopenams from a single precursor readily prepared from penicillin G.These penams have been converted into the corresponding 2-heterosubstituted penems.