78840-04-7Relevant articles and documents
Photoinduced DNA Interstrand Cross-Linking by Benzene Derivatives: Leaving Groups Determine the Efficiency of the Cross-Linker
Fan, Heli,Peng, Xiaohua
, p. 493 - 506 (2020/12/22)
We have synthesized and characterized two small libraries of 2-OMe or 2-NO2-benzene analogues 2a-i and 3a-i containing a wide variety of leaving groups. Irradiation of these compounds at 350 nm generated benzyl radicals that were spontaneously oxidized to
Studies on the total synthesis of lactonamycin: Synthesis of the fused pentacyclic B-F ring unit
Jacques, Sylvain A.,Michaelis, Simon,Gebhardt, Bjoern,Blum, Andreas,Lebrasseur, Nathalie,Larrosa, Igor,White, Andrew J. P.,Barrett, Anthony G. M.
experimental part, p. 107 - 113 (2012/01/15)
This paper describes an approach towards the total synthesis of lactonamycin with the elaboration of a key pentacyclic unit. Key steps include the synthesis of benzyl bromide 8 in eight steps and 23 % overall yield starting from 4-methoxyphenol; a high-yi
Studies on the total synthesis of lactonamycin: Synthesis of the CDEF ring system
Wehlan, Hermut,Jezek, Eva,Lebrasseur, Nathalie,Pave, Gregoire,Roulland, Emmanuel,White, Andrew J. P.,Burrows, Jeremy N.,Barrett, Anthony G. M.
, p. 8151 - 8158 (2007/10/03)
A concise and efficient synthesis of the tetracyclic CDEF ring system of lactonamycin (1) is described. The key step involved the Lewis acid mediated, intramolecular Friedel-Crafts acylation of carboxylic acid 6 to produce the tetracyclic CDEF core struct
Synthesis and Enantioselective Coloration of Optically Active Azophenolic Acerands incorporating Two 1,1'-Binaphthyl Moieties as the Chiral Centre
Yamamoto, Koji,Isoue, Koichiro,Sakata, Yoshiteru,Kaneda, Takahiro
, p. 791 - 793 (2007/10/02)
Two chiral azophenolic acerands 2 and 3 with two 1,1'-binaphthyl moieties as the chiral centre have been prepred, and their chiral recognition properties based on enantiomeric amine-selective coloration have been examined; the host 3 shows a higher enanti
Bis(bioreductive) alkylating agents: Synthesis and biological activity in a nude mouse human carcinoma model
Witiak, Donald T.,Kamat, Prabhakar L.,Allison, Debra L.,Liebowitz, Stephen M.,Glaser, Ronald,et al.
, p. 1679 - 1686 (2007/10/02)
Chemical investigations leading to the construction of bis(bioreductive) alkylating agents having both conformationally restricted and mobile spacer regions are described. Two targets having the conformationally mobile ethylene spacer group, namely, 2,2'-ethylenebis[6-(hydroxymethyl)-p-benzoquinone] diacetate (3b) and 2,2'-ethylenebis[6-(bromomethyl)-p-benzoquinone] (3c), were studied in vivo and in vitro using an established epithelial/Burkitt lymphoma hybrid cell line (D98/HR1) previously shown to induce carcinomas in nude mice. Inactivity of both test compounds in vitro, the relative resistance of these cells to test drugs in vitro, and the selective antitumor properties of the bis(bromomethyl) analogue in vivo lead to the proposal that this compound undergoes bioreduction to an alkylating species in the hypoxic core of the tumor, thereby exerting its action.
Light Absorption and Emission Properties of Cyanovinyl-substituted Dimethoxybenzenes
Chu, Kwong Yung,Griffiths, John,Ward, David
, p. 3701 - 3721 (2007/10/02)
Synthetic routes to a range of dyes based on cyanovinyl-substituted dimethoxybenzenes are described.The light absorption and fluorescence properties of these compounds in fluid solution at room temperature are discussed.