25224-72-0

Basic information

• Product Name: 1,3-Benzenedicarboxaldehyde, 2,5-dimethoxy-
• CAS NO: 25224-72-0
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• Mol File: 25224-72-0.mol

Chemical Properties

• CAS DataBase Reference: 1,3-Benzenedicarboxaldehyde, 2,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenedicarboxaldehyde, 2,5-dimethoxy-(25224-72-0)
• EPA Substance Registry System: 1,3-Benzenedicarboxaldehyde, 2,5-dimethoxy-(25224-72-0)

Safety Data

• Hazardous Substances Data: 25224-72-0(Hazardous Substances Data)

Upstream product

• 78840-04-7 [3-(hydroxymethyl)-2,5-dimethoxyphenyl]methanol 
• 129316-20-7 2,6-bis(bromomethylene)-4-methoxyphenol 
• 21893-97-0 2,6-bis(hydroxymethyl)-4-methoxyphenol 
• 50-00-0 formaldehyd 
• 72652-35-8 1,3-bis-bromomethyl-2,5-dimethoxy-benzene 
• 73289-61-9 2-hydroxy-5-methoxyisophthaldehyde 
• 74-88-4 methyl iodide 
• 67-64-1 acetone 
• 39000-58-3 1,4-dimethoxycyclohexa-1,4-diene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 129316-21-8 2,6-bis-1,4-dimethoxybenzene 
• 80777-85-1 2-Cyano-3-[3-(2,2-dicyano-vinyl)-2,5-dimethoxy-phenyl]-acrylonitrile 

Relevant articles and documents

Synthesis of 1,2,9,10-tetrahydroxy[2.2]metacyclophanes via pinacol coupling reaction of 1,3-benzenedicarboxyaldehydes

Tetrahydroxy[2.2]metacyclophanes are formed via the aluminium mediated pinacol coupling reaction of 1,3-benzenedicarboxaldehydes. The results indicate that the presence of functional groups in the aromatic ring of the dialdehydes plays an important role in the formation of the cyclophane structure. Intramolecular coupling reactions as well as a comparison of different reductive systems are discussed in the work.

Bis(bioreductive) alkylating agents: Synthesis and biological activity in a nude mouse human carcinoma model

Chemical investigations leading to the construction of bis(bioreductive) alkylating agents having both conformationally restricted and mobile spacer regions are described. Two targets having the conformationally mobile ethylene spacer group, namely, 2,2'-ethylenebis[6-(hydroxymethyl)-p-benzoquinone] diacetate (3b) and 2,2'-ethylenebis[6-(bromomethyl)-p-benzoquinone] (3c), were studied in vivo and in vitro using an established epithelial/Burkitt lymphoma hybrid cell line (D98/HR1) previously shown to induce carcinomas in nude mice. Inactivity of both test compounds in vitro, the relative resistance of these cells to test drugs in vitro, and the selective antitumor properties of the bis(bromomethyl) analogue in vivo lead to the proposal that this compound undergoes bioreduction to an alkylating species in the hypoxic core of the tumor, thereby exerting its action.

Light Absorption and Emission Properties of Cyanovinyl-substituted Dimethoxybenzenes

Synthetic routes to a range of dyes based on cyanovinyl-substituted dimethoxybenzenes are described.The light absorption and fluorescence properties of these compounds in fluid solution at room temperature are discussed.