788799-69-9

Usage

Uses

Used in Pharmaceutical Industry:
(S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid serves as a crucial building block for the synthesis of new drugs and therapeutic agents. Its presence in the development pipeline is attributed to its ability to facilitate the creation of molecules with potential medicinal applications, thereby expanding the range of treatments available for various diseases and conditions.
Used in Academic Research:
In academic settings, (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid is utilized as a key intermediate for the synthesis of novel compounds. Researchers leverage its structural attributes to explore new chemical spaces and investigate the properties and potential applications of newly synthesized entities.
Used in Organic Chemistry:
(S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid is applied in organic chemistry to develop new materials and compounds with specific properties. Its unique structure allows for the design and synthesis of molecules that can exhibit tailored characteristics, which can be beneficial in various chemical processes and applications.
Used in Materials Science:
Within the field of materials science, (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid is employed for the development of innovative materials. Its incorporation into material compositions can lead to the creation of substances with improved or unique properties, such as enhanced stability, reactivity, or selectivity, which can be advantageous in a range of technological and industrial applications.

InChI:InChI=1/C15H26N2O6/c1-14(2,3)22-12(20)16-7-8-17(10(9-16)11(18)19)13(21)23-15(4,5)6/h10H,7-9H2,1-6H3,(H,18,19)/t10-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 147650-70-2 (2S)-piperazine-2-carboxylic acid 

Downstream Products

• 958635-19-3 1,4-di-tert-butyl 2-methyl (2S)-piperazine-1,2,4-tricarboxylate 
• 892393-38-3 (-)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2S)-piperazinecarboxamide 
• 1932411-32-9 C₁₅H₂₉N₃O₄ 
• 314741-40-7 (3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester 
• 958635-18-2 tert-butyl (8aS)-3-oxotetrahydro-1,3-oxazolo[3,4-a]pyrazine-7(1H)-carboxylate 

Relevant academic research and scientific papers

Bis(vinylsulfonyl)piperazines as efficient linkers for highly homogeneous antibody-drug conjugates

Disulfide re-bridging strategy has demonstrated significant advantages in the construction of homogeneous antibody drug conjugates (ADCs). However, a major issue that disulfide scrambling at the hinge region of antibody leads to the formation of “half-antibody” has appeared for many re-bridging linkers. We present bis(vinylsulfonyl)piperazines (BVP) as efficient linkers to selectively re-bridge disulfides at the antigen-binding fragment (Fab) regions and produce highly homogeneous conjugates with a loading of two drugs without disulfide scrambling. We also found that optically active (S)-configuration linkers led to more sufficient conjugation compared with (R)-configuration. The BVP-linked ADCs demonstrated superior efficacy and antigen-selectivity in vitro cytotoxicity.

Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.

PYRAZOLOPYRIDINE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, co

TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, co

PIPERAZINES AS ANTI-OBESITY AGENTS

The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds, to processes for their preparation, and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.

A practical synthesis of differentially protected 2-(Hydroxymethyl) piperazines

(Chemical Equation Presented) An efficient and scalable synthesis of three differentially protected 2-(hydroxymefhyl)piperazines is presented, starting from optically active and commercially available (2S)-piperazine-2-carboxylic acid dihydrochloride. These synthetic building blocks are useful in the preparation of biologically active compounds and as chemical scaffolds for the construction of combinatorial libraries.

FARNESYL PROTEIN TRANSFERASE INHIBITORS AND METHODS FOR TREATING PROLIFERATIVE DISEASES

Disclosed are compounds of the Formula: (1.0) wherein the substituents are as defined herein. Also disclosed are uses of the compounds of formula 1.0 for the manufacture of a medicament for treating cancer and for inhibiting farnesyl protein transferase.