788799-69-9

Basic information

• Product Name: (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid
• Synonyms: 1,2,4-Piperazinetricarboxylic acid, 1,4-bis(1,1-diMethylethyl) ester, (2S)-;(S)-1-N-Boc-4-N-Boc-Piperazine-2-carboxylic acid;(S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid
• CAS NO: 788799-69-9
• Molecular Formula: C₁₅H₂₆N₂O₆
• Molecular Weight: 330.378
• Mol File: 788799-69-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 443.888°C at 760 mmHg
• Flash Point: 222.256°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid(788799-69-9)
• EPA Substance Registry System: (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid(788799-69-9)

Safety Data

• Hazardous Substances Data: 788799-69-9(Hazardous Substances Data)

Usage

General Description

(S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid is a chemical compound with the molecular formula C16H24N2O6. It is commonly used as a building block in the synthesis of complex organic molecules and pharmaceutical compounds. The compound has a piperazine ring and a carboxylic acid functional group, making it a versatile intermediate for the synthesis of various biologically active compounds. It is often used in the pharmaceutical industry for the development of new drugs and therapeutic agents, as well as in academic research for the synthesis of novel compounds. Additionally, it has potential applications in the field of organic chemistry and materials science for the development of new materials and compounds with specific properties.

InChI:InChI=1/C15H26N2O6/c1-14(2,3)22-12(20)16-7-8-17(10(9-16)11(18)19)13(21)23-15(4,5)6/h10H,7-9H2,1-6H3,(H,18,19)/t10-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 147650-70-2 (2S)-piperazine-2-carboxylic acid 

Downstream Products

• 958635-19-3 1,4-di-tert-butyl 2-methyl (2S)-piperazine-1,2,4-tricarboxylate 
• 1932411-32-9 C₁₅H₂₉N₃O₄ 
• 892393-38-3 (-)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2S)-piperazinecarboxamide 
• 314741-40-7 (3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester 
• 958635-18-2 tert-butyl (8aS)-3-oxotetrahydro-1,3-oxazolo[3,4-a]pyrazine-7(1H)-carboxylate 

Relevant articles and documents

Bis(vinylsulfonyl)piperazines as efficient linkers for highly homogeneous antibody-drug conjugates

Disulfide re-bridging strategy has demonstrated significant advantages in the construction of homogeneous antibody drug conjugates (ADCs). However, a major issue that disulfide scrambling at the hinge region of antibody leads to the formation of “half-antibody” has appeared for many re-bridging linkers. We present bis(vinylsulfonyl)piperazines (BVP) as efficient linkers to selectively re-bridge disulfides at the antigen-binding fragment (Fab) regions and produce highly homogeneous conjugates with a loading of two drugs without disulfide scrambling. We also found that optically active (S)-configuration linkers led to more sufficient conjugation compared with (R)-configuration. The BVP-linked ADCs demonstrated superior efficacy and antigen-selectivity in vitro cytotoxicity.

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PIPERAZINES AS ANTI-OBESITY AGENTS

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