78998-97-7Relevant academic research and scientific papers
Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP
Tang, Shuang-Qi,Bricard, Jacques,Schmitt, Martine,Bihel, Frédéric
supporting information, p. 844 - 848 (2019/01/30)
An efficient and user-friendly palladium(II) precatalyst, POxAP (post-oxidative-addition precatalyst), was identified for use in Fukuyama cross-coupling reactions. Suitable for storage under air, the POxAP precatalyst allowed reaction between thioesters and organozinc reagents with turnover numbers of ～90000. A series of 23 ketones were obtained with yields ranging from 53 to 99%. As proof of efficacy, an alternative approach was developed for the synthesis of a key precursor of the natural product isoprekinamycin.
Divergent Enantioselective Synthesis of (Nor)illudalane Sesquiterpenes via Pd0-Catalyzed Asymmetric C(sp3)-H Activation
Melot, Romain,Craveiro, Marcus V.,Bürgi, Thomas,Baudoin, Olivier
supporting information, p. 812 - 815 (2019/01/21)
A divergent enantioselective synthesis of (nor)illudalane sesquiterpenes was designed by using a Pd0-catalyzed asymmetric C(sp3)-H arylation as a key step to control the isolated, highly symmetric quaternary stereocenter of the targe
Total Synthesis of (Nor)illudalane Sesquiterpenes Based on a C(sp3)-H Activation Strategy
Melot, Romain,Craveiro, Marcus V.,Baudoin, Olivier
, p. 12933 - 12945 (2019/08/20)
Three (nor)illudalane sesquiterpenes were synthesized from a common intermediate in racemic and enantioenriched forms using Pd0-catalyzed C(sp3)-H arylation as a key step. The configuration of the isolated, highly symmetric quaternar
Enantioselective Approach to (-)-Hamigeran B and (-)-4-Bromohamigeran B via Catalytic Asymmetric Hydrogenation of Racemic Ketone to Assemble the Chiral Core Framework
Lin, Han,Xiao, Li-Jun,Zhou, Min-Jie,Yu, Hong-Ming,Xie, Jian-Hua,Zhou, Qi-Lin
supporting information, p. 1434 - 1437 (2016/04/01)
A new strategy featuring an iridium-catalyzed asymmetric hydrogenation of a racemic ketone via dynamic kinetic resolution to generate a cyclopentanol with three contiguous stereocenters and a SmI2-promoted pinacol coupling to install the six-me
Total Synthesis of Phenanthroviridin Aglycon: The First Naturally Occuring Benzophenanthridine
Gore, Makarand P.,Gould, Steven J.,Weller, Dwight D.
, p. 2289 - 2291 (2007/10/02)
The first synthesis of a naturally occurring benzophenanthridine has been accomplished via coupling of a cyanophthalide and a substituted bromocinnamate and subsequent transformation of the resulting aryl naphthoquinone carboxylate via formylation, Hof
