790230-09-0

Basic information

• Product Name: 2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester
• Synonyms: 2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester
• CAS NO: 790230-09-0
• Molecular Weight: 429.516
• Mol File: 790230-09-0.mol

Chemical Properties

• CAS DataBase Reference: 2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester(790230-09-0)
• EPA Substance Registry System: 2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester(790230-09-0)

Safety Data

• Hazardous Substances Data: 790230-09-0(Hazardous Substances Data)

Upstream product

• 142031-67-2 methyl 4-bromo-3-(bromomethyl)benzoate 
• 148547-19-7 4-Bromo-3-methylbenzoic acid methyl ester 
• 100-39-0 benzyl bromide 
• 6967-82-4 2-bromo-5-methylbenzoic acid 
• 790230-06-7 4-bromo-3-(1,3-dioxolan-2-yl)-N-isobutylbenzamide 
• 790230-05-6 4-bromo-3-hydroxymethyl-N-isobutylbenzamide 
• 254746-41-3 methyl 3-(acetyloxy)methyl-4-bromobenzoate 
• 790230-04-5 4-bromo-3-(hydroxymethyl)benzoic acid 
• 790230-08-9 benzyl 2-bromo-5-methylbenzoate 
• 790230-07-8 {2-formyl-4-[(isobutylamino)carbonyl]penyl}boronic acid 

Downstream Products

• 790230-34-1 2'-(3-carbamoyl-phenylcarbamoyl)-4-isobutylcarbamoyl-4'-methyl-biphenyl-2-carboxylic acid methyl ester 
• 790230-10-3 2'-benzyl 2-methyl 4-(isobutylamino)carbonyl-4'-methylbiphenyl-2,2'-dicarboxylate 

Relevant articles and documents

Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand

Inhibition of tissue factor/factor VIIa complex (TF/FVIIa) is an attractive strategy for antithrombotic therapies. We began with an investigation of a non-amidine TF/FVIIa inhibitor based on a modification of amidine compound 1. Optimization of the substituents on the P1 phenyl portion of the compound 1 led to a neutral or less basic alternative for the 4-amidinophenyl moiety. By further optimization of the substituents on the central phenyl ring, a highly potent and selective TF/FVIIa inhibitor 17d was discovered.