79039-71-7

Upstream product

• 2894-51-1 2-amino-4'-chlorobenzophenone 
• 1956-39-4 4-chloroacetophenone oxime 
• 1679-18-1 4-Chlorophenylboronic acid 
• 703-61-7 2,4-dichloroquinoline 
• 70254-44-3 2,4-dihydroxyquinoline 
• 1073-67-2 4-vinylbenzyl chloride 
• 586-96-9 Nitrosobenzene 

Relevant academic research and scientific papers

Lewis acid catalyzed reactivity switch: Pseudo three-component annulation of nitrosoarenes and (epoxy)styrenes

A Lewis acid catalyzed annulation reaction via arene functionalization of nitrosoarenes and C-C cleavage of (epoxy)styrene to provide arylquinolines is reported. The Lewis acid catalyst altered the annulation pattern providing arylquinolines instead of oxazolidines. The reaction with styrene resulted in a mixture of 2,4-diarylquinoline and 4-Arylquinoline, while only 3-Arylquinoline was formed from the reaction of epoxystyrene. This journal is

QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS

The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.

Preparation of 2,4-Diarylquinolines and Substituted Dihydrobenzacridines by the Condensation of Certain C(α),O-Dilithiooximes with 2-Aminobenzophenones

C(α),O-Dilithiooximes were prepared in an excess of lithium diisopropylamide and condensed with several 2-aminobenzophenones, followed by acid hydrolysis of the oximes to the ketones, which then underwent cyclodehydration to give substituted quinolines or dihydrobenzacridines.