79109-29-8

Upstream product

• 5397-76-2 1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 67605-65-6 5,10,15-tris(phenyl)-20-(4-nitrophenyl)porphyrin 
• 917-23-7 5,15,10,20-tetraphenylporphyrin 
• 1445098-30-5 4,4-difluoro-1,3-dimethyl-8-(4-nitrophenyl)-4-bora-3a,4a-diaza-s-indacene 
• 1445098-35-0 4,4-difluoro-1,3-dimethyl-8-(4-aminoophenyl)-4-bora-3a,4a-diaza-s-indacene 

Relevant academic research and scientific papers

Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11

Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic, diagnosis of biofilm-associated infections relies heavily on culturing methods, which fail to detect nonculturable bacteria. Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagnosis of pathogenic bacterial infection. Herein, we report a novel fluorescent probe, CDy11 (compound of designation yellow 11), which targets amyloid in the Pseudomonas aeruginosa biofilm matrix through a diversity oriented fluorescent library approach (DOFLA). CDy11 was further demonstrated for in vivo imaging of P. aeruginosa in implant and corneal infection mice models.

CHEMICAL FLUORESCENT PROBES FOR DETECTING BIOFILMS

The present invention relates to a family of fluorescent compounds based on the BODIPY scaffold, and methods for the preparation of said compounds. The present invention further relates to the use of said compounds for the detection of bacterial biofilms, wherein the bacterial biofilm comprises Pseudomonas aeruginosa and the compound specifically binds to a Fap protein of Pseudomonas aeruginosa, or wherein the compound specifically binds to bacterial cells that contain high levels of cyclic-di-guanosine-monophosphate (c-di-GMP).

BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS

The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Als

Visualization and isolation of langerhans islets by a fluorescent probe PiY

Lighting up the pancreas: A pancreatic beta cell selective probe PiY (red, see picture) was developed which stains Langerhans islets in live animals without toxicity or side effects. Through tail-vein injection, PiY allowed for a comparison of the islets between healthy and diabetic mice. PiY also facilitated the isolation of healthy Langerhans islets by using a fluorescence-guided surgical procedure. Copyright

Antifungal agents, II: Synthesis and antifungal activities of aryl-1H-pyrrol-2-yl-1H-imidazol-1-yl-methane derivatives with unsaturated chains

The synthesis and antifungal activities of aryl-1H-pyrrol-2-yl-1H-imidazol-1-yl-methanes having allyl, crotyl, and acrylate chains linked to the N-pyrrole atom and substituted at phenyl ring by Cl, F, CH3, and NO2 groups are reported